Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals
Postmortem brain studies of older drivers killed in car accidents indicate that many had Alzheimer disease (AD) neuropathologic changes. We examined whether AD biomarkers are related to driving performance among cognitively normal older adults. Individuals with normal cognition, aged 65+ years, and...
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| Veröffentlicht in: | Alzheimer disease and associated disorders 2017-01, Vol.31 (1), p.69-72 |
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| creator | Roe, Catherine M Barco, Peggy P Head, Denise M Ghoshal, Nupur Selsor, Natalie Babulal, Ganesh M Fierberg, Rebecca Vernon, Elizabeth K Shulman, Neal Johnson, Ann Fague, Scot Xiong, Chengjie Grant, Elizabeth A Campbell, Angela Ott, Brian R Holtzman, David M Benzinger, Tammie L.S Fagan, Anne M Carr, David B Morris, John C |
| description | Postmortem brain studies of older drivers killed in car accidents indicate that many had Alzheimer disease (AD) neuropathologic changes. We examined whether AD biomarkers are related to driving performance among cognitively normal older adults. Individuals with normal cognition, aged 65+ years, and driving at least once per week, were recruited. Participants (N=129) took part in clinical assessments, a driving test, and positron emission tomography imaging with Pittsburgh compound B (PIB) and/or cerebrospinal fluid (CSF) collection. General linear models tested whether the number of driving errors differed as a function of each of the biomarker variables (mean cortical binding potential for PIB, and CSF Aβ42, tau, ptau181, tau/Aβ42, ptau181/Aβ42). Higher ratios of CSF tau/Aβ42, ptau181/Aβ42, and PIB mean cortical binding potential, were associated with more driving errors (P |
| doi_str_mv | 10.1097/WAD.0000000000000154 |
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However, when combined, these changes may impact complex behaviors such as driving.</description><subject>Aged</subject><subject>Amyloid beta-Peptides - cerebrospinal fluid</subject><subject>Aniline Compounds</subject><subject>Asymptomatic Diseases</subject><subject>Automobile Driving</subject><subject>Biomarkers - cerebrospinal fluid</subject><subject>Brain - physiology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Positron-Emission Tomography - methods</subject><subject>tau Proteins - cerebrospinal fluid</subject><subject>Thiazoles</subject><issn>0893-0341</issn><issn>1546-4156</issn><issn>1546-4156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhi0EokvhHyDkIwdS_JU4uSAtWworVdADiKPlOJNdUyfe2slW---ZaktVOOCDLc088854XkJec3bGWaPf_1yen7HHh5fqCVngXRWKl9VTsmB1IwsmFT8hL3L-hYyWJXtOToTmom7KZkF2y-EQou_oerAbP27e0RUkaFPMOz_aQC_CjMmPPg42XUPK9CpB591Ez5PfI0-vIPUxDXZ0QJdDxMgqbkY_-T2EA_16lwp0PXZId7MN-SV51uMDr-7fU_Lj4tP31Zfi8tvn9Wp5WbiS1aroJOullm2pgEMJWgEI1enOCYFxq5Vua9bgHhxveylbsCAA404LqWwj5Sn5cNTdze0AnYNxSjaYXfL4k4OJ1pu_M6Pfmk3cG2xf1lqhwNt7gRRvZsiTGXx2EIIdIc7Z8FpUFc5QCUTVEXW4t5ygf2jDmbkzy6BZ5l-zsOzN4xEfiv64g0B9BG5jmHD512G-hWS2YMO0_b_2b4kKo1c</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Roe, Catherine M</creator><creator>Barco, Peggy P</creator><creator>Head, Denise M</creator><creator>Ghoshal, Nupur</creator><creator>Selsor, Natalie</creator><creator>Babulal, Ganesh M</creator><creator>Fierberg, Rebecca</creator><creator>Vernon, Elizabeth K</creator><creator>Shulman, Neal</creator><creator>Johnson, Ann</creator><creator>Fague, Scot</creator><creator>Xiong, Chengjie</creator><creator>Grant, Elizabeth A</creator><creator>Campbell, Angela</creator><creator>Ott, Brian R</creator><creator>Holtzman, David M</creator><creator>Benzinger, Tammie L.S</creator><creator>Fagan, Anne M</creator><creator>Carr, David B</creator><creator>Morris, John C</creator><general>Copyright Wolters Kluwer Health, Inc. 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However, when combined, these changes may impact complex behaviors such as driving.</abstract><cop>United States</cop><pub>Copyright Wolters Kluwer Health, Inc. All rights reserved</pub><pmid>27128959</pmid><doi>10.1097/WAD.0000000000000154</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Alzheimer disease and associated disorders, 2017-01, Vol.31 (1), p.69-72 |
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| subjects | Aged Amyloid beta-Peptides - cerebrospinal fluid Aniline Compounds Asymptomatic Diseases Automobile Driving Biomarkers - cerebrospinal fluid Brain - physiology Female Humans Male Positron-Emission Tomography - methods tau Proteins - cerebrospinal fluid Thiazoles |
| title | Amyloid Imaging, Cerebrospinal Fluid Biomarkers Predict Driving Performance Among Cognitively Normal Individuals |
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