Verotoxin and ricin have novel effects on preproendothelin-1 expression but fail to modify nitric oxide synthase (ecNOS) expression and NO production in vascular endothelium

Interaction of bipartite Escherichia coli O157-derived verotoxins (VTs) 1 and 2 (Shiga toxin 1 and 2) with vascular endothelium is believed to play a central role in the pathogenesis of the thrombotic microangiopathy and ischemic lesions characteristic of hemolytic uremic syndrome and of E. coli O15...

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Veröffentlicht in:	The Journal of clinical investigation 1998-01, Vol.101 (2), p.372-382
Hauptverfasser:	Bitzan, M M, Wang, Y, Lin, J, Marsden, P A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aspartic Acid Endopeptidases - genetics Bacterial Toxins - toxicity Cattle Cells, Cultured Dactinomycin - pharmacology Endothelin-1 Endothelin-Converting Enzymes Endothelins - genetics Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Gene Expression - drug effects Hemolytic-Uremic Syndrome - etiology Metalloendopeptidases Nitric Oxide - biosynthesis Nitric Oxide Synthase - genetics Nitric Oxide Synthase Type III Protein Precursors - genetics Ricin - toxicity RNA, Messenger - analysis Shiga Toxin 1 Shiga Toxin 2
Online-Zugang:	Volltext
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