Implications of Hypoxia in Breast Cancer Metastasis to Bone
Most solid tumors contain regions of hypoxia in which increased cell proliferation promotes increased oxygen consumption and the condition is further exacerbated as cancer cells become localized far from a functional blood vessel, further decreasing the oxygen supply. An important mechanism that pro...
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| Veröffentlicht in: | International journal of molecular sciences 2016-10, Vol.17 (10), p.1669-1669 |
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| container_title | International journal of molecular sciences |
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| creator | Gilkes, Daniele M |
| description | Most solid tumors contain regions of hypoxia in which increased cell proliferation promotes increased oxygen consumption and the condition is further exacerbated as cancer cells become localized far from a functional blood vessel, further decreasing the oxygen supply. An important mechanism that promotes cell adaptation to hypoxic conditions is the expression of hypoxia-inducible factors (HIFs). Hypoxia-inducible factors transcriptionally regulate many genes involved in the invasion and metastasis of breast cancer cells. Patients, whose primary tumor biopsies show high HIF expression levels, have a greater risk of metastasis. The current review will highlight the potential role of hypoxia in breast cancer metastasis to the bone by considering the regulation of many steps in the metastatic process that include invasion, migration, margination and extravasation, as well as homing signals and regulation of the bone microenvironment. |
| doi_str_mv | 10.3390/ijms17101669 |
| format | Article |
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An important mechanism that promotes cell adaptation to hypoxic conditions is the expression of hypoxia-inducible factors (HIFs). Hypoxia-inducible factors transcriptionally regulate many genes involved in the invasion and metastasis of breast cancer cells. Patients, whose primary tumor biopsies show high HIF expression levels, have a greater risk of metastasis. The current review will highlight the potential role of hypoxia in breast cancer metastasis to the bone by considering the regulation of many steps in the metastatic process that include invasion, migration, margination and extravasation, as well as homing signals and regulation of the bone microenvironment.</description><subject>Basic Helix-Loop-Helix Transcription Factors - metabolism</subject><subject>Bone Neoplasms - secondary</subject><subject>Bones</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Epithelial-Mesenchymal Transition</subject><subject>Female</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>Metastasis</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplastic Stem Cells - metabolism</subject><subject>Review</subject><subject>Tumors</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc1Lw0AQxRdRbK3ePEvAiwerO5vsRxAEW9QWKl70vGyyG92SZONuKva_N6W1VE-eZob58XgzD6FTwFdxnOJrO68CcMDAWLqH-pAQMsSY8f2dvoeOQphjTGJC00PUI5xjhhPeRzfTqiltrlrr6hC5IposG_dlVWTraOSNCm00VnVufPRk2m5SwYaoddHI1eYYHRSqDOZkUwfo9eH-ZTwZzp4fp-O72TBPEtoOaZprSLAQIjWYGE0LBgy0MJykrDA6SwgA1YprSDPKCspVpgnFWoFgYFQ8QLdr3WaRVUbnpm69KmXjbaX8Ujpl5e9Nbd_lm_uUFAvKu6MH6GIj4N3HwoRWVjbkpixVbdwiSBAUcwGU8X-gMY1F0j2yQ8__oHO38HX3iRW18k6BdtTlmsq9C8GbYusbsFwFKHcD7PCz3Vu38E9i8TekBpVk</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Gilkes, Daniele M</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20161001</creationdate><title>Implications of Hypoxia in Breast Cancer Metastasis to Bone</title><author>Gilkes, Daniele M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-59cd1408889e02ed5f6161d8e7296fedb42115da7d19b56f57abd250da1861ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Basic Helix-Loop-Helix Transcription Factors - 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| subjects | Basic Helix-Loop-Helix Transcription Factors - metabolism Bone Neoplasms - secondary Bones Breast cancer Breast Neoplasms - pathology Epithelial-Mesenchymal Transition Female Humans Hypoxia Matrix Metalloproteinases - metabolism Metastasis Neoplasm Invasiveness Neoplastic Stem Cells - metabolism Review Tumors |
| title | Implications of Hypoxia in Breast Cancer Metastasis to Bone |
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