Repurposing cephalosporin antibiotics as pro-senescent radiosensitizers

Radiation therapy remains a significant therapeutic modality in the treatment of cancer. An attractive strategy would be to enhance the benefits of ionizing radiation (IR)with radiosensitizers. A high-content drug repurposing screen of approved and investigational agents, natural products and other...

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Veröffentlicht in:	Oncotarget 2016-06, Vol.7 (23), p.33919-33933
Hauptverfasser:	Labay, Edwardine, Mauceri, Helena J, Efimova, Elena V, Flor, Amy C, Sutton, Harold G, Kron, Stephen J, Weichselbaum, Ralph R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Cell Proliferation - drug effects Cell Proliferation - radiation effects Cellular Senescence - drug effects Cellular Senescence - radiation effects Cephalosporins - pharmacology DNA Damage - drug effects DNA Damage - radiation effects Dose-Response Relationship, Drug Dose-Response Relationship, Radiation Drug Repositioning Female Humans MCF-7 Cells Mice, Inbred C57BL Oxidative Stress - drug effects Oxidative Stress - radiation effects Radiation-Sensitizing Agents - pharmacology Reactive Oxygen Species - metabolism Research Paper Time Factors Tumor Burden - drug effects Tumor Burden - radiation effects Xenograft Model Antitumor Assays
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