An integrated proteomics approach shows synaptic plasticity changes in an APP/PS1 Alzheimer's mouse model

The aim of this study was to elucidate the molecular signature of Alzheimer's disease-associated amyloid pathology.We used the double APPswe/PS1ΔE9 mouse, a widely used model of cerebral amyloidosis, to compare changes in proteome, including global phosphorylation and sialylated N-linked glycos...

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Veröffentlicht in:	Oncotarget 2016-06, Vol.7 (23), p.33627-33648
Hauptverfasser:	Kempf, Stefan J, Metaxas, Athanasios, Ibáñez-Vea, María, Darvesh, Sultan, Finsen, Bente, Larsen, Martin R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - pathology Alzheimer Disease - physiopathology Animals Disease Models, Animal Male Mice Mice, Transgenic Neuronal Plasticity Proteomics - methods Research Paper: Pathology
Online-Zugang:	Volltext
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