Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties

Cisplatin is an effective anticancer drug; however, cisplatin use often leads to nephrotoxicity, which limits its clinical effectiveness. In this study, we determined the effect of dichloroacetate, a novel anticancer agent, in a mouse model of cisplatin-induced AKI. Pretreatment with dichloroacetate...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2016-11, Vol.27 (11), p.3331-3344
Hauptverfasser:	Galgamuwa, Ramindhu, Hardy, Kristine, Dahlstrom, Jane E, Blackburn, Anneke C, Wium, Elize, Rooke, Melissa, Cappello, Jean Y, Tummala, Padmaja, Patel, Hardip R, Chuah, Aaron, Tian, Luyang, McMorrow, Linda, Board, Philip G, Theodoratos, Angelo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Basic Research Cisplatin - adverse effects Cisplatin - therapeutic use Dichloroacetic Acid - therapeutic use Female Kidney Diseases - chemically induced Kidney Diseases - prevention & control Male Mice Mice, Inbred BALB C
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