Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha

Endothelial cells initiate the inflammatory response by recruiting and activating leukocytes. IL-6 is not an agonist for this, but we found soluble IL-6 receptor alpha-subunit (IL-6Ralpha), with their constitutive IL-6 synthesis, stimulated endothelial cells to synthesize E-selectin, intracellular a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 1997-12, Vol.100 (11), p.2752-2756
Hauptverfasser:	Modur, V, Li, Y, Zimmerman, G A, Prescott, S M, McIntyre, T M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured E-Selectin - biosynthesis Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Humans Inflammation Intercellular Adhesion Molecule-1 - biosynthesis Interleukin-6 - biosynthesis Interleukin-8 - biosynthesis Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism Rabbits Receptors, Interleukin-6 - biosynthesis Receptors, Interleukin-6 - metabolism Signal Transduction Solubility Vascular Cell Adhesion Molecule-1 - biosynthesis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!