Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha
Endothelial cells initiate the inflammatory response by recruiting and activating leukocytes. IL-6 is not an agonist for this, but we found soluble IL-6 receptor alpha-subunit (IL-6Ralpha), with their constitutive IL-6 synthesis, stimulated endothelial cells to synthesize E-selectin, intracellular a...
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| Veröffentlicht in: | The Journal of clinical investigation 1997-12, Vol.100 (11), p.2752-2756 |
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| container_issue | 11 |
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| container_title | The Journal of clinical investigation |
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| creator | Modur, V Li, Y Zimmerman, G A Prescott, S M McIntyre, T M |
| description | Endothelial cells initiate the inflammatory response by recruiting and activating leukocytes. IL-6 is not an agonist for this, but we found soluble IL-6 receptor alpha-subunit (IL-6Ralpha), with their constitutive IL-6 synthesis, stimulated endothelial cells to synthesize E-selectin, intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, IL-6, and IL-8, and to bind neutrophils. Neutrophils express significant amounts of IL-6Ralpha and upon stimulation shed it: this material activates endothelial cells through a newly constituted IL-6 receptor. Retrograde signaling from PMN activated in the extravascular compartment to surrounding endothelial cells will recruit more and a wider variety of leukocytes. The limiting signal is a soluble receptor, not a cytokine. |
| doi_str_mv | 10.1172/jci119821 |
| format | Article |
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IL-6 is not an agonist for this, but we found soluble IL-6 receptor alpha-subunit (IL-6Ralpha), with their constitutive IL-6 synthesis, stimulated endothelial cells to synthesize E-selectin, intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, IL-6, and IL-8, and to bind neutrophils. Neutrophils express significant amounts of IL-6Ralpha and upon stimulation shed it: this material activates endothelial cells through a newly constituted IL-6 receptor. Retrograde signaling from PMN activated in the extravascular compartment to surrounding endothelial cells will recruit more and a wider variety of leukocytes. The limiting signal is a soluble receptor, not a cytokine.</description><subject>Animals</subject><subject>Cells, Cultured</subject><subject>E-Selectin - biosynthesis</subject><subject>Endothelium, Vascular - cytology</subject><subject>Endothelium, Vascular - metabolism</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Intercellular Adhesion Molecule-1 - biosynthesis</subject><subject>Interleukin-6 - biosynthesis</subject><subject>Interleukin-8 - biosynthesis</subject><subject>Neutrophils - cytology</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - metabolism</subject><subject>Rabbits</subject><subject>Receptors, Interleukin-6 - biosynthesis</subject><subject>Receptors, Interleukin-6 - metabolism</subject><subject>Signal Transduction</subject><subject>Solubility</subject><subject>Vascular Cell Adhesion Molecule-1 - biosynthesis</subject><issn>0021-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtLxDAUhbNQxnF04Q8QshJcVJsmfS1cyOCTAUF0HdL0ts2YJjVphfn3Zphh0FXg3u-cm8NB6ILEN4Tkye1aKkLKIiFHaB7HCYnKnBYn6NT7dRwTxlI2Q7OSFmFczpF9h9HZ1okasDKNFn0vRus22KvWCK1Mixtne2xgCtzQKe3xaDGY2o4daCU0lqDDsAoSq6dKb31GcBqmL2WiDDuQMARLLPTQiTN03Ajt4Xz_LtDn48PH8jlavT29LO9XkWQ0HSOSslqmFVQNY5I2QHJRJzWlIQ_N8ywLASWhTCZZWJUMKMmLgtZpkVRlRhmhC3S38x2mqodaghmd0Hxwqhduw61Q_P_GqI639oenccHyMuiv9npnvyfwI--V3yYVBuzkeTjKspiyAF7vQOms9w6aww0S820h_HX5sisksJd_P3Ug923QX9UVixY</recordid><startdate>19971201</startdate><enddate>19971201</enddate><creator>Modur, V</creator><creator>Li, Y</creator><creator>Zimmerman, G A</creator><creator>Prescott, S M</creator><creator>McIntyre, T M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19971201</creationdate><title>Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha</title><author>Modur, V ; Li, Y ; Zimmerman, G A ; Prescott, S M ; McIntyre, T M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-154dc5bebf44c3fe17ad2d3302137766198c134c26e1794e317883d582b963413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Cells, Cultured</topic><topic>E-Selectin - biosynthesis</topic><topic>Endothelium, Vascular - cytology</topic><topic>Endothelium, Vascular - metabolism</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Intercellular Adhesion Molecule-1 - biosynthesis</topic><topic>Interleukin-6 - biosynthesis</topic><topic>Interleukin-8 - biosynthesis</topic><topic>Neutrophils - cytology</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - metabolism</topic><topic>Rabbits</topic><topic>Receptors, Interleukin-6 - biosynthesis</topic><topic>Receptors, Interleukin-6 - metabolism</topic><topic>Signal Transduction</topic><topic>Solubility</topic><topic>Vascular Cell Adhesion Molecule-1 - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Modur, V</creatorcontrib><creatorcontrib>Li, Y</creatorcontrib><creatorcontrib>Zimmerman, G A</creatorcontrib><creatorcontrib>Prescott, S M</creatorcontrib><creatorcontrib>McIntyre, T M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Modur, V</au><au>Li, Y</au><au>Zimmerman, G A</au><au>Prescott, S M</au><au>McIntyre, T M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>1997-12-01</date><risdate>1997</risdate><volume>100</volume><issue>11</issue><spage>2752</spage><epage>2756</epage><pages>2752-2756</pages><issn>0021-9738</issn><abstract>Endothelial cells initiate the inflammatory response by recruiting and activating leukocytes. IL-6 is not an agonist for this, but we found soluble IL-6 receptor alpha-subunit (IL-6Ralpha), with their constitutive IL-6 synthesis, stimulated endothelial cells to synthesize E-selectin, intracellular adhesion molecule-1, vascular cellular adhesion molecule-1, IL-6, and IL-8, and to bind neutrophils. Neutrophils express significant amounts of IL-6Ralpha and upon stimulation shed it: this material activates endothelial cells through a newly constituted IL-6 receptor. Retrograde signaling from PMN activated in the extravascular compartment to surrounding endothelial cells will recruit more and a wider variety of leukocytes. The limiting signal is a soluble receptor, not a cytokine.</abstract><cop>United States</cop><pmid>9389739</pmid><doi>10.1172/jci119821</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Animals Cells, Cultured E-Selectin - biosynthesis Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Humans Inflammation Intercellular Adhesion Molecule-1 - biosynthesis Interleukin-6 - biosynthesis Interleukin-8 - biosynthesis Neutrophils - cytology Neutrophils - drug effects Neutrophils - metabolism Rabbits Receptors, Interleukin-6 - biosynthesis Receptors, Interleukin-6 - metabolism Signal Transduction Solubility Vascular Cell Adhesion Molecule-1 - biosynthesis |
| title | Retrograde inflammatory signaling from neutrophils to endothelial cells by soluble interleukin-6 receptor alpha |
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