RNA assemblages orchestrate complex cellular processes

Eukaryotic mRNAs are monocistronic, and therefore mechanisms exist that coordinate the synthesis of multiprotein complexes in order to obtain proper stoichiometry at the appropriate intracellular locations. RNA‐binding proteins containing low‐complexity sequences are prone to generate liquid droplet...

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Veröffentlicht in:	BioEssays 2016-07, Vol.38 (7), p.674-681
Hauptverfasser:	Nielsen, Finn Cilius, Hansen, Heidi Theil, Christiansen, Jan
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Animals biogenesis droplets Drosophila Drosophila - genetics Drosophila - metabolism Humans liquid droplet low-complexity sequence messenger RNA multiprotein complexes phase transition Phase transitions post-transcriptional RNA regulon Prospects & Overviews Ribonucleoproteins - metabolism RNA assemblage RNA Processing, Post-Transcriptional RNA, Messenger - metabolism RNA-binding protein RNA-binding proteins RNA-Binding Proteins - metabolism RNP granule Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism separation stoichiometry
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