Unidirectional Eph/ephrin signaling creates a cortical actomyosin differential to drive cell segregation

Cell segregation is the process by which cells self-organize to establish developmental boundaries, an essential step in tissue formation. Cell segregation is a common outcome of Eph/ephrin signaling, but the mechanisms remain unclear. In craniofrontonasal syndrome, X-linked mosaicism for ephrin-B1...

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Veröffentlicht in:	The Journal of cell biology 2016-10, Vol.215 (2), p.217-229
Hauptverfasser:	O'Neill, Audrey K, Kindberg, Abigail A, Niethamer, Terren K, Larson, Andrew R, Ho, Hsin-Yi Henry, Greenberg, Michael E, Bush, Jeffrey O
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Actomyosin - metabolism Animals Cell Count Cell Differentiation Cells Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Ephrin-B1 - metabolism Green Fluorescent Proteins - metabolism HEK293 Cells Humans Kinases Mice Models, Biological Neuroepithelial Cells - cytology Neuroepithelial Cells - metabolism Receptors, Eph Family - metabolism rho-Associated Kinases - metabolism Rodents Signal Transduction Tissues
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