In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13

IL-10 and IL-13 have powerful antiinflammatory activities in vitro and in vivo. In the IgG immune complex model of lung injury in rats, exogenously administered IL-10 or IL-13 have recently been shown to suppress neutrophil recruitment and ensuing lung injury by greatly depressing pulmonary producti...

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Veröffentlicht in:	The Journal of clinical investigation 1997-11, Vol.100 (10), p.2443-2448
Hauptverfasser:	Lentsch, A B, Shanley, T P, Sarma, V, Ward, P A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Antibody Complex Cell Nucleus - drug effects Cell Nucleus - metabolism DNA-Binding Proteins - biosynthesis I-kappa B Proteins Immunoglobulin G Interleukin-10 - pharmacology Interleukin-13 - pharmacology Lung - drug effects Lung - immunology Lung - metabolism Macrophages, Alveolar - drug effects Macrophages, Alveolar - immunology Macrophages, Alveolar - metabolism Male NF-kappa B - antagonists & inhibitors NF-kappa B - biosynthesis NF-KappaB Inhibitor alpha Rats Recombinant Proteins - pharmacology RNA, Messenger - biosynthesis Serum Albumin, Bovine Transcription, Genetic - drug effects
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