Sodium Channel Blockers for the Treatment of Neuropathic Pain
Drugs that block voltage-gated sodium channels are efficacious in the management of neuropathic pain. Accordingly, this class of ion channels has been a major focus of analgesic research both in academia and in the pharmaceutical/biotechnology industry. In this article, we review the history of the...
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| Veröffentlicht in: | Neurotherapeutics 2009-10, Vol.6 (4), p.663-678 |
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| creator | Bhattacharya, Anindya Wickenden, Alan D. Chaplan, Sandra R. |
| description | Drugs that block voltage-gated sodium channels are efficacious in the management of neuropathic pain. Accordingly, this class of ion channels has been a major focus of analgesic research both in academia and in the pharmaceutical/biotechnology industry. In this article, we review the history of the use of sodium channel blockers, describe the current status of sodium channel drug discovery, highlight the challenges and hurdles to attain sodium channel subtype selectivity, and review the potential usefulness of selective sodium channel blockers in neuropathic pain. |
| doi_str_mv | 10.1016/j.nurt.2009.08.001 |
| format | Article |
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Accordingly, this class of ion channels has been a major focus of analgesic research both in academia and in the pharmaceutical/biotechnology industry. 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| subjects | Animals Biomedical and Life Sciences Biomedicine Cellular biology Drug Discovery Humans Neuralgia - drug therapy Neuralgia - physiopathology Neurobiology Neurology neuropathic pain Neurosciences Neurosurgery Pain Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - physiopathology selectivity Sodium Sodium channel Sodium Channel Blockers - therapeutic use Sodium Channels - genetics Sodium Channels - metabolism subtype Transmitter and Receptor Manipulation |
| title | Sodium Channel Blockers for the Treatment of Neuropathic Pain |
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