Pathogenic antibodies inhibit the binding of apolipoproteins to megalin/gp330 in passive Heymann nephritis

Megalin/gp330 is an endocytic receptor that internalizes multiple ligands including apolipoproteins E (apo E) and B100 (apo B). Megalin is the main antigenic target in passive Heymann nephritis (pHN), where it binds circulating autoantibodies leading to the formation of subepithelial immune deposits...

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Veröffentlicht in:	The Journal of clinical investigation 1997-11, Vol.100 (9), p.2303-2309
Hauptverfasser:	Kerjaschki, D, Exner, M, Ullrich, R, Susani, M, Curtiss, L K, Witztum, J L, Farquhar, M G, Orlando, R A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigen-Antibody Complex - metabolism Apolipoproteins - metabolism Apolipoproteins B - metabolism Apolipoproteins E - metabolism Autoantibodies - immunology Autoantigens - metabolism Endocytosis Fluorescent Antibody Technique, Indirect Glomerulonephritis - immunology Glomerulonephritis - metabolism Heymann Nephritis Antigenic Complex Immunization, Passive Immunohistochemistry Kidney - metabolism Lipoproteins, VLDL - metabolism Male Membrane Glycoproteins - immunology Membrane Glycoproteins - metabolism Rats Rats, Sprague-Dawley Receptors, LDL - metabolism
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