YAP Inhibition by Resveratrol via Activation of AMPK Enhances the Sensitivity of Pancreatic Cancer Cells to Gemcitabine

Resveratrol, a natural polyphenol present in most plants, inhibits the growth of numerous cancers both in vitro and in vivo. Aberrant expression of YAP has been reported to activate multiple growth-regulatory pathways and confer anti-apoptotic abilities to many cancer cells. However, the role of res...

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Veröffentlicht in:	Nutrients 2016-09, Vol.8 (10), p.546
Hauptverfasser:	Jiang, Zhengdong, Chen, Xin, Chen, Ke, Sun, Liankang, Gao, Luping, Zhou, Cancan, Lei, Meng, Duan, Wanxing, Wang, Zheng, Ma, Qingyong, Ma, Jiguang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - antagonists & inhibitors Adaptor Proteins, Signal Transducing - metabolism AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - therapeutic use apoptosis bioactive properties Cell Line, Tumor Deoxycytidine - analogs & derivatives Deoxycytidine - therapeutic use drug therapy Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - pharmacology Gene Expression Regulation, Enzymologic - drug effects Humans neoplasm cells Pancreatic cancer pancreatic neoplasms Pancreatic Neoplasms - drug therapy Phosphoproteins - antagonists & inhibitors Phosphoproteins - metabolism phosphorylation polyphenols protein kinases Resveratrol RNA Interference Signal Transduction - drug effects small interfering RNA Stilbenes - pharmacology transcription (genetics) Transcription Factors
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