Effects of an oral iron chelator, deferasirox, on advanced hepatocellular carcinoma

AIM To evaluate the inhibitory effects of deferasirox(DFX) against hepatocellular carcinoma(HCC) through basic and clinical studies.METHODS In the basic study, the effect of DFX was investigated in three hepatoma cell lines(Hep G2, Hep3 B, and Huh7), as well as in an N-nitrosodiethylamine-induced mu...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2016-10, Vol.22 (40), p.8967-8977
Hauptverfasser:	Saeki, Issei, Yamamoto, Naoki, Yamasaki, Takahiro, Takami, Taro, Maeda, Masaki, Fujisawa, Koichi, Iwamoto, Takuya, Matsumoto, Toshihiko, Hidaka, Isao, Ishikawa, Tsuyoshi, Uchida, Koichi, Tani, Kenji, Sakaida, Isao
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Animals Benzoates - therapeutic use Carcinoma, Hepatocellular - drug therapy Clinical Trials Study Drug Screening Assays, Antitumor Female Hep G2 Cells Humans Iron Chelating Agents - therapeutic use Liver Neoplasms, Experimental - drug therapy Male Mice Mice, Inbred C57BL Middle Aged Triazoles - therapeutic use
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