Hemodynamic forces induce the expression of heme oxygenase in cultured vascular smooth muscle cells

Both nitric oxide (NO) and carbon monoxide (CO) are vessel wall-derived messenger molecules that cause platelet inhibition and vasodilation by activating guanylyl cyclase in target cells. Since vascular smooth muscle cells (SMCs) are exposed to shear and tensile stresses, this study examined the eff...

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Veröffentlicht in:	The Journal of clinical investigation 1997-08, Vol.100 (3), p.589-596
Hauptverfasser:	Wagner, C T, Durante, W, Christodoulides, N, Hellums, J D, Schafer, A I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Culture Media, Conditioned Heme Oxygenase (Decyclizing) - biosynthesis Hemodynamics Muscle, Smooth, Vascular - enzymology Muscle, Smooth, Vascular - physiopathology Platelet Aggregation Rats Stress, Mechanical
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