Identification of New Structural Fragments for the Design of Lactate Dehydrogenase A Inhibitors

Human lactate dehydrogenase A plays an important role in the glucose metabolism of tumor cells and constitutes an attractive target for chemotherapy. Molecular fragments able to bind in the active site of this enzyme and form hydrogen bonds with the Arg168 guanidinium group, as well as additional in...

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Veröffentlicht in:	Actanaturae 2016-07, Vol.8 (3), p.118-122
Hauptverfasser:	Nilov, D K, Kulikov, A V, Prokhorova, E A, Švedas, V K
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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