Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

The generation of strain-specific neutralizing antibodies against influenza A virus is known to confer potent protection against homologous infections. The majority of these antibodies bind to the hemagglutinin (HA) head domain and function by blocking the receptor binding site, preventing infection...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-10, Vol.113 (42), p.11931-11936
Hauptverfasser:	He, Wenqian, Tan, Gene S., Mullarkey, Caitlin E., Lee, Amanda J., Lam, Mannie Man Wai, Krammer, Florian, Henry, Carole, Wilson, Patrick C., Ashkar, Ali A., Palese, Peter, Miller, Matthew S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antibody Affinity - immunology Antibody-Dependent Cell Cytotoxicity Antigens Antigens, Viral - chemistry Antigens, Viral - immunology Antigens, Viral - metabolism Binding sites Binding, Competitive Biological Sciences Biomarkers Cell Line Cells Cytotoxicity Epitopes - immunology Epitopes - metabolism Glycoproteins Hemagglutinin Glycoproteins, Influenza Virus - chemistry Hemagglutinin Glycoproteins, Influenza Virus - immunology Hemagglutinin Glycoproteins, Influenza Virus - metabolism Humans Immunoglobulin Fc Fragments - immunology Immunoglobulin Fc Fragments - metabolism Immunoglobulin G - immunology Influenza Influenza A virus Influenza A virus - immunology Influenza, Human - immunology Influenza, Human - metabolism Influenza, Human - virology Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Models, Biological Orthomyxoviridae Protein Binding Protein Interaction Domains and Motifs Receptors, Fc - metabolism
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