Counter‐regulatory paracrine actions of FGF‐23 and 1,25(OH)2D in macrophages
Mechanisms underlying the association between fibroblastic growth factor 23 (FGF‐23) and inflammation are uncertain. We found that FGF‐23 was markedly up‐regulated in LPS/INF‐γ‐induced proinflammatory M1 macrophages and Hyp mouse‐derived peritoneal macrophages, but not in IL‐4‐induced M2 anti‐inflam...
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| Veröffentlicht in: | FEBS letters 2016-01, Vol.590 (1), p.53-67 |
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| container_title | FEBS letters |
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| creator | Han, Xiaobin Li, Linqiang Yang, Jiancheng King, Gwendalyn Xiao, Zhousheng Quarles, Leigh Darryl Ellmeier, Wilfried |
| description | Mechanisms underlying the association between fibroblastic growth factor 23 (FGF‐23) and inflammation are uncertain. We found that FGF‐23 was markedly up‐regulated in LPS/INF‐γ‐induced proinflammatory M1 macrophages and Hyp mouse‐derived peritoneal macrophages, but not in IL‐4‐induced M2 anti‐inflammatory macrophages. NF‐КB and JAK/STAT1 pathways mediated the increased transcription of FGF‐23 in response to M1 polarization. FGF‐23 stimulated TNF‐α, but not IL‐6, expression in M0 macrophages and suppressed Arginase‐1 expression in M2 macrophages through FGFR‐mediated mechanisms. 1,25(OH)2D stimulated Arginase‐1 expression and inhibited FGF‐23 stimulation of TNF‐α. FGF‐23 has proinflammatory paracrine functions and counter‐regulatory actions to 1,25(OH)2D on innate immune responses. |
| doi_str_mv | 10.1002/1873-3468.12040 |
| format | Article |
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We found that FGF‐23 was markedly up‐regulated in LPS/INF‐γ‐induced proinflammatory M1 macrophages and Hyp mouse‐derived peritoneal macrophages, but not in IL‐4‐induced M2 anti‐inflammatory macrophages. NF‐КB and JAK/STAT1 pathways mediated the increased transcription of FGF‐23 in response to M1 polarization. FGF‐23 stimulated TNF‐α, but not IL‐6, expression in M0 macrophages and suppressed Arginase‐1 expression in M2 macrophages through FGFR‐mediated mechanisms. 1,25(OH)2D stimulated Arginase‐1 expression and inhibited FGF‐23 stimulation of TNF‐α. FGF‐23 has proinflammatory paracrine functions and counter‐regulatory actions to 1,25(OH)2D on innate immune responses.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1002/1873-3468.12040</identifier><identifier>PMID: 26762170</identifier><language>eng</language><subject>1,25(OH)2D ; FGF‐23 ; interferon gamma ; Klotho ; lipopolysaccharide ; macrophages</subject><ispartof>FEBS letters, 2016-01, Vol.590 (1), p.53-67</ispartof><rights>2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2F1873-3468.12040$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2F1873-3468.12040$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids></links><search><creatorcontrib>Han, Xiaobin</creatorcontrib><creatorcontrib>Li, Linqiang</creatorcontrib><creatorcontrib>Yang, Jiancheng</creatorcontrib><creatorcontrib>King, Gwendalyn</creatorcontrib><creatorcontrib>Xiao, Zhousheng</creatorcontrib><creatorcontrib>Quarles, Leigh Darryl</creatorcontrib><creatorcontrib>Ellmeier, Wilfried</creatorcontrib><title>Counter‐regulatory paracrine actions of FGF‐23 and 1,25(OH)2D in macrophages</title><title>FEBS letters</title><description>Mechanisms underlying the association between fibroblastic growth factor 23 (FGF‐23) and inflammation are uncertain. We found that FGF‐23 was markedly up‐regulated in LPS/INF‐γ‐induced proinflammatory M1 macrophages and Hyp mouse‐derived peritoneal macrophages, but not in IL‐4‐induced M2 anti‐inflammatory macrophages. NF‐КB and JAK/STAT1 pathways mediated the increased transcription of FGF‐23 in response to M1 polarization. FGF‐23 stimulated TNF‐α, but not IL‐6, expression in M0 macrophages and suppressed Arginase‐1 expression in M2 macrophages through FGFR‐mediated mechanisms. 1,25(OH)2D stimulated Arginase‐1 expression and inhibited FGF‐23 stimulation of TNF‐α. FGF‐23 has proinflammatory paracrine functions and counter‐regulatory actions to 1,25(OH)2D on innate immune responses.</description><subject>1,25(OH)2D</subject><subject>FGF‐23</subject><subject>interferon gamma</subject><subject>Klotho</subject><subject>lipopolysaccharide</subject><subject>macrophages</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNpVkL1OwzAURi0EoqUws3oEiZRrO7aTBQlK0yJVKgPM1k3itKnSpHJSUDcegWfkSUhaVInp_n33DIeQawZDBsDvWaCFJ3wVDBkHH05I_7g5JX0A5ntSh6JHLup6Be0csPCc9LjSijMNffI6qrZlY93P17ezi22BTeV2dIMOE5eXlmLS5FVZ0yqj0SRqU1xQLFPK7ri8mU9v-TPNS7pu09VmiQtbX5KzDIvaXv3VAXmPxm-jqTebT15GjzNvxXUIXqys0iyWPOOQqiAFGyTAmPYDbVUiJOgQYyFlhpnEUITKxhYZSOVnjClUYkAeDtzNNl7bNLFl47AwG5ev0e1Mhbn5fynzpVlUH6ZDSx62AHUAfOaF3R0fGZjOrOk8ms6j2Zs10fiJ7zvxCxBcbIo</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Han, Xiaobin</creator><creator>Li, Linqiang</creator><creator>Yang, Jiancheng</creator><creator>King, Gwendalyn</creator><creator>Xiao, Zhousheng</creator><creator>Quarles, Leigh Darryl</creator><creator>Ellmeier, Wilfried</creator><scope>5PM</scope></search><sort><creationdate>201601</creationdate><title>Counter‐regulatory paracrine actions of FGF‐23 and 1,25(OH)2D in macrophages</title><author>Han, Xiaobin ; Li, Linqiang ; Yang, Jiancheng ; King, Gwendalyn ; Xiao, Zhousheng ; Quarles, Leigh Darryl ; Ellmeier, Wilfried</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j2790-b6e671b52f20d68d0e8c0117487e6c35079ab355faf5a9396ebea10564f116a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>1,25(OH)2D</topic><topic>FGF‐23</topic><topic>interferon gamma</topic><topic>Klotho</topic><topic>lipopolysaccharide</topic><topic>macrophages</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Xiaobin</creatorcontrib><creatorcontrib>Li, Linqiang</creatorcontrib><creatorcontrib>Yang, Jiancheng</creatorcontrib><creatorcontrib>King, Gwendalyn</creatorcontrib><creatorcontrib>Xiao, Zhousheng</creatorcontrib><creatorcontrib>Quarles, Leigh Darryl</creatorcontrib><creatorcontrib>Ellmeier, Wilfried</creatorcontrib><collection>PubMed Central (Full Participant titles)</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Xiaobin</au><au>Li, Linqiang</au><au>Yang, Jiancheng</au><au>King, Gwendalyn</au><au>Xiao, Zhousheng</au><au>Quarles, Leigh Darryl</au><au>Ellmeier, Wilfried</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Counter‐regulatory paracrine actions of FGF‐23 and 1,25(OH)2D in macrophages</atitle><jtitle>FEBS letters</jtitle><date>2016-01</date><risdate>2016</risdate><volume>590</volume><issue>1</issue><spage>53</spage><epage>67</epage><pages>53-67</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Mechanisms underlying the association between fibroblastic growth factor 23 (FGF‐23) and inflammation are uncertain. We found that FGF‐23 was markedly up‐regulated in LPS/INF‐γ‐induced proinflammatory M1 macrophages and Hyp mouse‐derived peritoneal macrophages, but not in IL‐4‐induced M2 anti‐inflammatory macrophages. NF‐КB and JAK/STAT1 pathways mediated the increased transcription of FGF‐23 in response to M1 polarization. FGF‐23 stimulated TNF‐α, but not IL‐6, expression in M0 macrophages and suppressed Arginase‐1 expression in M2 macrophages through FGFR‐mediated mechanisms. 1,25(OH)2D stimulated Arginase‐1 expression and inhibited FGF‐23 stimulation of TNF‐α. FGF‐23 has proinflammatory paracrine functions and counter‐regulatory actions to 1,25(OH)2D on innate immune responses.</abstract><pmid>26762170</pmid><doi>10.1002/1873-3468.12040</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | FEBS letters, 2016-01, Vol.590 (1), p.53-67 |
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| subjects | 1,25(OH)2D FGF‐23 interferon gamma Klotho lipopolysaccharide macrophages |
| title | Counter‐regulatory paracrine actions of FGF‐23 and 1,25(OH)2D in macrophages |
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