Hydrogen Sulfide in Renal Physiology and Disease
Hydrogen sulfide (H2S) has only recently gained recognition for its physiological effects. It is synthesized widely in the mammalian tissues and regulates several biologic processes ranging from development, angiogenesis, neurotransmission to protein synthesis. Recent Advances: The aim of this revie...
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| Veröffentlicht in: | Antioxidants & redox signaling 2016-11, Vol.25 (13), p.720-731 |
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| creator | Feliers, Denis Lee, Hak Joo Kasinath, Balakuntalam S |
| description | Hydrogen sulfide (H2S) has only recently gained recognition for its physiological effects. It is synthesized widely in the mammalian tissues and regulates several biologic processes ranging from development, angiogenesis, neurotransmission to protein synthesis. Recent Advances: The aim of this review is to critically evaluate the evidence for a role for H2S in kidney function and disease.
H2S regulates fundamental kidney physiologic processes such as glomerular filtration and sodium reabsorption. In kidney disease states H2S appears to play a complex role in a context-dependent manner. In some disease states such as ischemia-reperfusion and diabetic kidney disease it can serve as an agent that ameliorates kidney injury. In other diseases such as cis-platinum-induced kidney disease it may mediate kidney injury although more investigation is needed. Recent studies have revealed that the actions of nitric oxide and H2S may be integrated in kidney cells.
Further studies are needed to understand the full impact of H2S on kidney physiology. As it is endowed with the properties of regulating blood flow, oxidative stress, and inflammation, H2S should be investigated for its role in inflammatory and toxic diseases of the kidney. Such in-depth exploration may identify specific kidney diseases in which H2S may constitute a unique target for therapeutic intervention. Antioxid. Redox Signal. 25, 720-731. |
| doi_str_mv | 10.1089/ars.2015.6596 |
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H2S regulates fundamental kidney physiologic processes such as glomerular filtration and sodium reabsorption. In kidney disease states H2S appears to play a complex role in a context-dependent manner. In some disease states such as ischemia-reperfusion and diabetic kidney disease it can serve as an agent that ameliorates kidney injury. In other diseases such as cis-platinum-induced kidney disease it may mediate kidney injury although more investigation is needed. Recent studies have revealed that the actions of nitric oxide and H2S may be integrated in kidney cells.
Further studies are needed to understand the full impact of H2S on kidney physiology. As it is endowed with the properties of regulating blood flow, oxidative stress, and inflammation, H2S should be investigated for its role in inflammatory and toxic diseases of the kidney. Such in-depth exploration may identify specific kidney diseases in which H2S may constitute a unique target for therapeutic intervention. Antioxid. Redox Signal. 25, 720-731.</description><identifier>ISSN: 1523-0864</identifier><identifier>EISSN: 1557-7716</identifier><identifier>DOI: 10.1089/ars.2015.6596</identifier><identifier>PMID: 27005700</identifier><language>eng</language><publisher>United States: Mary Ann Liebert, Inc</publisher><subject>Angiogenesis ; Animals ; Blood flow ; Diabetes mellitus ; Diseases ; Exploration ; Forum Review ; Humans ; Hydrogen sulfide ; Hydrogen Sulfide - metabolism ; Ischemia ; Kidney - metabolism ; Kidney - physiology ; Kidney diseases ; Kidney Diseases - metabolism ; Kidneys ; Neurotransmission ; Nitric oxide ; Nitric Oxide - metabolism ; Oxidative Stress ; Physiological effects ; Physiology ; Platinum ; Protein biosynthesis ; Protein synthesis ; Proteins ; Reabsorption ; Reperfusion ; Signal Transduction ; Sodium ; Toxic diseases</subject><ispartof>Antioxidants & redox signaling, 2016-11, Vol.25 (13), p.720-731</ispartof><rights>Copyright Mary Ann Liebert, Inc. Nov 1, 2016</rights><rights>Copyright 2016, Mary Ann Liebert, Inc. 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-71d2b15282935bc3556c0bed2ec180cf8ebcc95cb3f52a3b7561986ef36e19aa3</citedby><cites>FETCH-LOGICAL-c448t-71d2b15282935bc3556c0bed2ec180cf8ebcc95cb3f52a3b7561986ef36e19aa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27005700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feliers, Denis</creatorcontrib><creatorcontrib>Lee, Hak Joo</creatorcontrib><creatorcontrib>Kasinath, Balakuntalam S</creatorcontrib><title>Hydrogen Sulfide in Renal Physiology and Disease</title><title>Antioxidants & redox signaling</title><addtitle>Antioxid Redox Signal</addtitle><description>Hydrogen sulfide (H2S) has only recently gained recognition for its physiological effects. It is synthesized widely in the mammalian tissues and regulates several biologic processes ranging from development, angiogenesis, neurotransmission to protein synthesis. Recent Advances: The aim of this review is to critically evaluate the evidence for a role for H2S in kidney function and disease.
H2S regulates fundamental kidney physiologic processes such as glomerular filtration and sodium reabsorption. In kidney disease states H2S appears to play a complex role in a context-dependent manner. In some disease states such as ischemia-reperfusion and diabetic kidney disease it can serve as an agent that ameliorates kidney injury. In other diseases such as cis-platinum-induced kidney disease it may mediate kidney injury although more investigation is needed. Recent studies have revealed that the actions of nitric oxide and H2S may be integrated in kidney cells.
Further studies are needed to understand the full impact of H2S on kidney physiology. As it is endowed with the properties of regulating blood flow, oxidative stress, and inflammation, H2S should be investigated for its role in inflammatory and toxic diseases of the kidney. Such in-depth exploration may identify specific kidney diseases in which H2S may constitute a unique target for therapeutic intervention. Antioxid. Redox Signal. 25, 720-731.</description><subject>Angiogenesis</subject><subject>Animals</subject><subject>Blood flow</subject><subject>Diabetes mellitus</subject><subject>Diseases</subject><subject>Exploration</subject><subject>Forum Review</subject><subject>Humans</subject><subject>Hydrogen sulfide</subject><subject>Hydrogen Sulfide - metabolism</subject><subject>Ischemia</subject><subject>Kidney - metabolism</subject><subject>Kidney - physiology</subject><subject>Kidney diseases</subject><subject>Kidney Diseases - metabolism</subject><subject>Kidneys</subject><subject>Neurotransmission</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Oxidative Stress</subject><subject>Physiological effects</subject><subject>Physiology</subject><subject>Platinum</subject><subject>Protein biosynthesis</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Reabsorption</subject><subject>Reperfusion</subject><subject>Signal Transduction</subject><subject>Sodium</subject><subject>Toxic diseases</subject><issn>1523-0864</issn><issn>1557-7716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctLw0AQxhdRbK0evUrAi5fUfWQ3uxdB6qNCQfFxXjabSZuSZutuI-S_N6G1qIdhBubHN48PoXOCxwRLdW18GFNM-FhwJQ7QkHCexmlKxGFfUxZjKZIBOglhiTGmhOBjNKApxryLIcLTNvduDnX01lRFmUNU1tEr1KaKXhZtKF3l5m1k6jy6KwOYAKfoqDBVgLNdHqGPh_v3yTSePT8-TW5nsU0SuYlTktOsmy-pYjyzjHNhcQY5BUsktoWEzFrFbcYKTg3LUi6IkgIKJoAoY9gI3Wx11022gtxCvfGm0mtfroxvtTOl_tupy4Weuy_NcaoSgjuBq52Ad58NhI1elcFCVZkaXBM0kSylSiZMdejlP3TpGt_9IGhKGEsSKjjvqHhLWe9C8FDslyFY917ozgvde6F7Lzr-4vcFe_rn-ewblg2ERw</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Feliers, Denis</creator><creator>Lee, Hak Joo</creator><creator>Kasinath, Balakuntalam S</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>5PM</scope></search><sort><creationdate>20161101</creationdate><title>Hydrogen Sulfide in Renal Physiology and Disease</title><author>Feliers, Denis ; Lee, Hak Joo ; Kasinath, Balakuntalam S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-71d2b15282935bc3556c0bed2ec180cf8ebcc95cb3f52a3b7561986ef36e19aa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Blood flow</topic><topic>Diabetes mellitus</topic><topic>Diseases</topic><topic>Exploration</topic><topic>Forum Review</topic><topic>Humans</topic><topic>Hydrogen sulfide</topic><topic>Hydrogen Sulfide - metabolism</topic><topic>Ischemia</topic><topic>Kidney - metabolism</topic><topic>Kidney - physiology</topic><topic>Kidney diseases</topic><topic>Kidney Diseases - metabolism</topic><topic>Kidneys</topic><topic>Neurotransmission</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Oxidative Stress</topic><topic>Physiological effects</topic><topic>Physiology</topic><topic>Platinum</topic><topic>Protein biosynthesis</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Reabsorption</topic><topic>Reperfusion</topic><topic>Signal Transduction</topic><topic>Sodium</topic><topic>Toxic diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feliers, Denis</creatorcontrib><creatorcontrib>Lee, Hak Joo</creatorcontrib><creatorcontrib>Kasinath, Balakuntalam S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antioxidants & redox signaling</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feliers, Denis</au><au>Lee, Hak Joo</au><au>Kasinath, Balakuntalam S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hydrogen Sulfide in Renal Physiology and Disease</atitle><jtitle>Antioxidants & redox signaling</jtitle><addtitle>Antioxid Redox Signal</addtitle><date>2016-11-01</date><risdate>2016</risdate><volume>25</volume><issue>13</issue><spage>720</spage><epage>731</epage><pages>720-731</pages><issn>1523-0864</issn><eissn>1557-7716</eissn><abstract>Hydrogen sulfide (H2S) has only recently gained recognition for its physiological effects. It is synthesized widely in the mammalian tissues and regulates several biologic processes ranging from development, angiogenesis, neurotransmission to protein synthesis. Recent Advances: The aim of this review is to critically evaluate the evidence for a role for H2S in kidney function and disease.
H2S regulates fundamental kidney physiologic processes such as glomerular filtration and sodium reabsorption. In kidney disease states H2S appears to play a complex role in a context-dependent manner. In some disease states such as ischemia-reperfusion and diabetic kidney disease it can serve as an agent that ameliorates kidney injury. In other diseases such as cis-platinum-induced kidney disease it may mediate kidney injury although more investigation is needed. Recent studies have revealed that the actions of nitric oxide and H2S may be integrated in kidney cells.
Further studies are needed to understand the full impact of H2S on kidney physiology. As it is endowed with the properties of regulating blood flow, oxidative stress, and inflammation, H2S should be investigated for its role in inflammatory and toxic diseases of the kidney. Such in-depth exploration may identify specific kidney diseases in which H2S may constitute a unique target for therapeutic intervention. Antioxid. Redox Signal. 25, 720-731.</abstract><cop>United States</cop><pub>Mary Ann Liebert, Inc</pub><pmid>27005700</pmid><doi>10.1089/ars.2015.6596</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Angiogenesis Animals Blood flow Diabetes mellitus Diseases Exploration Forum Review Humans Hydrogen sulfide Hydrogen Sulfide - metabolism Ischemia Kidney - metabolism Kidney - physiology Kidney diseases Kidney Diseases - metabolism Kidneys Neurotransmission Nitric oxide Nitric Oxide - metabolism Oxidative Stress Physiological effects Physiology Platinum Protein biosynthesis Protein synthesis Proteins Reabsorption Reperfusion Signal Transduction Sodium Toxic diseases |
| title | Hydrogen Sulfide in Renal Physiology and Disease |
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