$Gli-1/PI3K/AKT/NF-kB pathway mediates resistance to radiation and is a target for reversion of responses in refractory acute myeloid leukemia cells$

Gli-1/PI3K/AKT/NF-kB pathway mediates resistance to radiation and is a target for reversion of responses in refractory acute myeloid leukemia cells

Total body irradiation combined with chemotherapy is currently the most effective procedure as a preparative myeloablative regimen. However, resistance to radiotherapy and chemotherapy in refractory acute myeloid leukemia is associated with short-time recurrence after allogeneic hematopoietic stem c...

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Veröffentlicht in:	Oncotarget 2016-05, Vol.7 (22), p.33004-33015
Hauptverfasser:	Li, Xiaodong, Chen, Fang, Zhu, Qiuhua, Ding, Bingjie, Zhong, Qingxiu, Huang, Kaikai, Jiang, Xuejie, Wang, Zhixiang, Yin, Changxin, Zhu, Yufeng, Li, Zhen, Meng, Fanyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Female HL-60 Cells Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - radiotherapy Mice Mice, Inbred BALB C Mice, Nude NF-kappa B - metabolism Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Radiation Tolerance Research Paper Signal Transduction Xenograft Model Antitumor Assays Zinc Finger Protein GLI1 - metabolism
Online-Zugang:	Volltext
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