Non-thermal plasma-induced apoptosis is modulated by ATR- and PARP1-mediated DNA damage responses and circadian clock

Non-thermal plasma (NTP) has been emerging as a potential cancer therapeutic. However, the practical use of NTP as a cancer therapy requires a better understanding of the precise mechanisms underlying NTP-induced DNA damage responses in order to achieve optimal efficacy. It has been shown that the a...

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Veröffentlicht in:	Oncotarget 2016-05, Vol.7 (22), p.32980-32989
Hauptverfasser:	Choi, Ji Ye, Joh, Hea Min, Park, Jeong-Min, Kim, Min Ji, Chung, Tae Hun, Kang, Tae-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals Apoptosis - drug effects Apoptosis - genetics Ataxia Telangiectasia Mutated Proteins - genetics Ataxia Telangiectasia Mutated Proteins - metabolism Cell Line, Tumor Circadian Clocks - drug effects Circadian Clocks - genetics DNA Damage Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - therapy Melanoma - genetics Melanoma - metabolism Melanoma - pathology Melanoma - therapy Mice Mice, Knockout Plasma Gases - pharmacology Poly (ADP-Ribose) Polymerase-1 - genetics Poly (ADP-Ribose) Polymerase-1 - metabolism Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Research Paper
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