Fluid shear stress induces epithelial-mesenchymal transition (EMT) in Hep-2 cells

Laryngeal squamous cell carcinoma (LSCC) is one of the most commonly diagnosed malignancies with high occurrence of tumor metastasis, which usually exposes to fluid shear stress (FSS) in lymphatic channel and blood vessel. Epithelial-mesenchymal transition (EMT) is an important mechanism that induce...

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Veröffentlicht in:	Oncotarget 2016-05, Vol.7 (22), p.32876-32892
Hauptverfasser:	Liu, Shuangfeng, Zhou, Fating, Shen, Yang, Zhang, Yingying, Yin, Hongmei, Zeng, Ye, Liu, Jingxia, Yan, Zhiping, Liu, Xiaoheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - metabolism beta Catenin - metabolism Cadherins - metabolism Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Line, Tumor Cell Movement Cell Shape Epithelial-Mesenchymal Transition Head and Neck Neoplasms - genetics Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Humans Laryngeal Neoplasms - genetics Laryngeal Neoplasms - metabolism Laryngeal Neoplasms - pathology Mechanotransduction, Cellular Phosphatidylinositol 3-Kinase - metabolism Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Pseudopodia - metabolism Pseudopodia - pathology Research Paper RNA Interference Snail Family Transcription Factors - genetics Snail Family Transcription Factors - metabolism Squamous Cell Carcinoma of Head and Neck Stress, Mechanical Time Factors Transfection Tumor Microenvironment
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