UBE2D3 gene overexpression increases radiosensitivity of EC109 esophageal cancer cells in vitro and in vivo

Ubiquitin-conjugating enzyme E2D3 (UBE2D3), a key component in ubiquitin (Ub) proteasome system, plays a crucial role in tumorigenesis. We previously found that it is bound to hTERT, and UBE2D3 could attenuate radiosensitivity of human breast cancer cells. Here we investigated a contributing role of...

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Veröffentlicht in:	Oncotarget 2016-05, Vol.7 (22), p.32543-32553
Hauptverfasser:	Gao, Xiaojia, Wang, Wenbo, Yang, Hui, Wu, Lin, He, Zhongshi, Zhou, Shuliang, Zhao, Hong, Fu, Zhenming, Zhou, Fuxiang, Zhou, Yunfeng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle - drug effects Cell Cycle - radiation effects Cell Line, Tumor Esophageal Neoplasms - enzymology Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophageal Neoplasms - radiotherapy Female Gene Expression Humans Male Mice Mice, Inbred BALB C Mice, Nude Radiation Tolerance Research Paper RNA, Messenger - genetics RNA, Messenger - metabolism Telomerase - genetics Telomerase - metabolism Ubiquitin-Conjugating Enzymes - biosynthesis Ubiquitin-Conjugating Enzymes - genetics Ubiquitination - drug effects Ubiquitination - radiation effects
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