Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism

The goal of this study was to determine if depletion of glutathione (GSH) and inhibition of thioredoxin (Trx) reductase (TrxR) activity could enhance radiation responses in human breast cancer stem cells by a mechanism involving thiol-dependent oxidative stress. The following were used to inhibit GS...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Radiation research 2016-10, Vol.186 (4), p.385-395
Hauptverfasser: Rodman, Samuel N., Spence, Jacquelyn M., Ronnfeldt, Tyler J., Zhu, Yueming, Solst, Shane R., O'Neill, Rebecca A., Allen, Bryan G., Guan, Xiangming, Spitz, Douglas R., Fath, Melissa A.
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!