Emodin ameliorates bleomycin-induced pulmonary fibrosis in rats by suppressing epithelial-mesenchymal transition and fibroblast activation

Aberrant activation of TGF-β1 is frequently encountered and promotes epithelial-mesenchymal transition (EMT) and fibroblast activation in pulmonary fibrosis. The present study investigated whether emodin mediates its effect via suppressing TGF-β1-induced EMT and fibroblast activation in bleomycin (B...

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Veröffentlicht in:	Scientific reports 2016-10, Vol.6 (1), p.35696-35696, Article 35696
Hauptverfasser:	Guan, Ruijuan, Wang, Xia, Zhao, Xiaomei, Song, Nana, Zhu, Jimin, Wang, Jijiang, Wang, Jin, Xia, Chunmei, Chen, Yonghua, Zhu, Danian, Shen, Linlin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 13/95 14/19 631/80/304 692/699/1785 82/80 96/2 A549 Cells Alveolar Epithelial Cells - drug effects Alveolar Epithelial Cells - metabolism Alveoli Animals Apoptosis Bleomycin Bleomycin - pharmacology Cell Differentiation - drug effects Cell Line, Tumor Cell Proliferation - drug effects Embryo fibroblasts Embryos Emodin Emodin - pharmacology Epithelial-Mesenchymal Transition - drug effects Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - metabolism Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibrosis Humanities and Social Sciences Humans Inactivation Lung - drug effects Lung - metabolism Lung diseases Male MAP Kinase Signaling System - drug effects Mesenchyme multidisciplinary Pulmonary fibrosis Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - drug therapy Pulmonary Fibrosis - metabolism Rats Rats, Sprague-Dawley Respiratory function Rodents Science Signal Transduction - drug effects Smad2 protein Smad2 Protein - metabolism Smad3 protein Smad3 Protein - metabolism Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1
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