Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins

Aggregation and retention of LDL in the arterial wall are key events in atherogenesis, but the mechanisms in vivo are not known. Previous work from our laboratories has shown that exposure of LDL to bacterial sphingomyelinase (SMase) in vitro leads to the formation of LDL aggregates that can be reta...

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Veröffentlicht in:	The Journal of clinical investigation 1996-09, Vol.98 (6), p.1455-1464
Hauptverfasser:	Schissel, S L, Tweedie-Hardman, J, Rapp, J H, Graham, G, Williams, K J, Tabas, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - enzymology Arteriosclerosis - enzymology Arteriosclerosis - metabolism Ceramides - analysis Foam Cells Humans Immunoblotting Lipoproteins, LDL - metabolism Rabbits Sphingomyelin Phosphodiesterase - metabolism Sphingomyelins - metabolism
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