Drug delivery into the cochlear apex: Improved control to sequentially affect finely spaced regions along the entire length of the cochlear spiral

•A new method to pharmacologically affect the cochlea is described.•Solutions are administered from a pipette sealed into the cochlear apex.•Controlled injections drive solutions towards the cochlear aqueduct in the base.•The method better controls drug concentrations than conventional cochlear perf...

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Veröffentlicht in:Journal of neuroscience methods 2016-11, Vol.273, p.201-209
Hauptverfasser: Lichtenhan, J.T., Hartsock, J., Dornhoffer, J.R., Donovan, K.M., Salt, A.N.
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Sprache:eng
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