Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction

Interferon-induced transmembrane proteins (IFITMs) restrict the entry of diverse enveloped viruses through incompletely understood mechanisms. While IFITMs are reported to inhibit HIV-1, their in vivo relevance is unclear. We show that IFITM sensitivity of HIV-1 strains is determined by the co-recep...

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Veröffentlicht in:	Cell host & microbe 2016-10, Vol.20 (4), p.429-442
Hauptverfasser:	Foster, Toshana L., Wilson, Harry, Iyer, Shilpa S., Coss, Karen, Doores, Katie, Smith, Sarah, Kellam, Paul, Finzi, Andrés, Borrow, Persephone, Hahn, Beatrice H., Neil, Stuart J.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Neutralizing - immunology Antigens, Differentiation - metabolism Antiviral Agents - metabolism antiviral restriction CD4 Cell Line co-receptor env Gene Products, Human Immunodeficiency Virus - genetics env Gene Products, Human Immunodeficiency Virus - immunology escape HIV Antibodies - immunology HIV-1 HIV-1 - immunology HIV-1 - physiology Host-Pathogen Interactions Humans IFITM Mutation neutralization transmitted founder virus type 1 interferon Viral Tropism Virus Internalization
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