Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar)
Viral diseases are among the main challenges in farming of Atlantic salmon (Salmo salar). The most prevalent viral diseases in Norwegian salmon aquaculture are heart and skeletal muscle inflammation (HSMI) caused by Piscine orthoreovirus (PRV), and pancreas disease (PD) caused by Salmonid alphavirus...
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| Veröffentlicht in: | Veterinary research (Paris) 2016-10, Vol.47 (1), p.107-107, Article 107 |
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| creator | Lund, Morten Røsæg, Magnus Vikan Krasnov, Aleksei Timmerhaus, Gerrit Nyman, Ingvild Berg Aspehaug, Vidar Rimstad, Espen Dahle, Maria Krudtaa |
| description | Viral diseases are among the main challenges in farming of Atlantic salmon (Salmo salar). The most prevalent viral diseases in Norwegian salmon aquaculture are heart and skeletal muscle inflammation (HSMI) caused by Piscine orthoreovirus (PRV), and pancreas disease (PD) caused by Salmonid alphavirus (SAV). Both PRV and SAV target heart and skeletal muscles, but SAV additionally targets exocrine pancreas. PRV and SAV are often present in the same locations and co-infections occur, but the effect of this crosstalk on disease development has not been investigated. In the present experiment, the effect of a primary PRV infection on subsequent SAV infection was studied. Atlantic salmon were infected with PRV by cohabitation, followed by addition of SAV shedder fish 4 or 10 weeks after the initial PRV infection. Histopathological evaluation, monitoring of viral RNA levels and host gene expression analysis were used to assess disease development. Significant reduction of SAV RNA levels and of PD specific histopathological changes were observed in the co-infected groups compared to fish infected by SAV only. A strong correlation was found between histopathological development and expression of disease related genes in heart. In conclusion, experimentally PRV infected salmon are less susceptible to secondary SAV infection and development of PD. |
| doi_str_mv | 10.1186/s13567-016-0389-y |
| format | Article |
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The most prevalent viral diseases in Norwegian salmon aquaculture are heart and skeletal muscle inflammation (HSMI) caused by Piscine orthoreovirus (PRV), and pancreas disease (PD) caused by Salmonid alphavirus (SAV). Both PRV and SAV target heart and skeletal muscles, but SAV additionally targets exocrine pancreas. PRV and SAV are often present in the same locations and co-infections occur, but the effect of this crosstalk on disease development has not been investigated. In the present experiment, the effect of a primary PRV infection on subsequent SAV infection was studied. Atlantic salmon were infected with PRV by cohabitation, followed by addition of SAV shedder fish 4 or 10 weeks after the initial PRV infection. Histopathological evaluation, monitoring of viral RNA levels and host gene expression analysis were used to assess disease development. Significant reduction of SAV RNA levels and of PD specific histopathological changes were observed in the co-infected groups compared to fish infected by SAV only. A strong correlation was found between histopathological development and expression of disease related genes in heart. In conclusion, experimentally PRV infected salmon are less susceptible to secondary SAV infection and development of PD.</description><identifier>ISSN: 1297-9716</identifier><identifier>ISSN: 0928-4249</identifier><identifier>EISSN: 1297-9716</identifier><identifier>DOI: 10.1186/s13567-016-0389-y</identifier><identifier>PMID: 27769313</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Alphavirus ; Alphavirus Infections - complications ; Alphavirus Infections - pathology ; Alphavirus Infections - veterinary ; Alphavirus Infections - virology ; Animals ; Atlantic salmon ; Diseases ; Fish Diseases - pathology ; Fish Diseases - virology ; Life Sciences ; Medical research ; Orthoreovirus ; Pancreatic Diseases - etiology ; Pancreatic Diseases - pathology ; Pancreatic Diseases - veterinary ; Pancreatic Diseases - virology ; Pancreatitis ; Prevention ; Reoviridae Infections - pathology ; Reoviridae Infections - veterinary ; Reverse Transcriptase Polymerase Chain Reaction - veterinary ; Risk factors ; RNA viruses ; Salmo salar - virology ; Veterinary medicine</subject><ispartof>Veterinary research (Paris), 2016-10, Vol.47 (1), p.107-107, Article 107</ispartof><rights>COPYRIGHT 2016 BioMed Central Ltd.</rights><rights>Copyright BioMed Central 2016</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>The Author(s) 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-f9e4148b7bf2dc9bfabf451392ce91a8e120559ff098c9f35751bf5dfc34a7f3</citedby><cites>FETCH-LOGICAL-c528t-f9e4148b7bf2dc9bfabf451392ce91a8e120559ff098c9f35751bf5dfc34a7f3</cites><orcidid>0000-0003-0380-084X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075195/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5075195/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27769313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02973469$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lund, Morten</creatorcontrib><creatorcontrib>Røsæg, Magnus Vikan</creatorcontrib><creatorcontrib>Krasnov, Aleksei</creatorcontrib><creatorcontrib>Timmerhaus, Gerrit</creatorcontrib><creatorcontrib>Nyman, Ingvild Berg</creatorcontrib><creatorcontrib>Aspehaug, Vidar</creatorcontrib><creatorcontrib>Rimstad, Espen</creatorcontrib><creatorcontrib>Dahle, Maria Krudtaa</creatorcontrib><title>Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar)</title><title>Veterinary research (Paris)</title><addtitle>Vet Res</addtitle><description>Viral diseases are among the main challenges in farming of Atlantic salmon (Salmo salar). The most prevalent viral diseases in Norwegian salmon aquaculture are heart and skeletal muscle inflammation (HSMI) caused by Piscine orthoreovirus (PRV), and pancreas disease (PD) caused by Salmonid alphavirus (SAV). Both PRV and SAV target heart and skeletal muscles, but SAV additionally targets exocrine pancreas. PRV and SAV are often present in the same locations and co-infections occur, but the effect of this crosstalk on disease development has not been investigated. In the present experiment, the effect of a primary PRV infection on subsequent SAV infection was studied. Atlantic salmon were infected with PRV by cohabitation, followed by addition of SAV shedder fish 4 or 10 weeks after the initial PRV infection. Histopathological evaluation, monitoring of viral RNA levels and host gene expression analysis were used to assess disease development. Significant reduction of SAV RNA levels and of PD specific histopathological changes were observed in the co-infected groups compared to fish infected by SAV only. A strong correlation was found between histopathological development and expression of disease related genes in heart. In conclusion, experimentally PRV infected salmon are less susceptible to secondary SAV infection and development of PD.</description><subject>Alphavirus</subject><subject>Alphavirus Infections - complications</subject><subject>Alphavirus Infections - pathology</subject><subject>Alphavirus Infections - veterinary</subject><subject>Alphavirus Infections - virology</subject><subject>Animals</subject><subject>Atlantic salmon</subject><subject>Diseases</subject><subject>Fish Diseases - pathology</subject><subject>Fish Diseases - virology</subject><subject>Life Sciences</subject><subject>Medical research</subject><subject>Orthoreovirus</subject><subject>Pancreatic Diseases - etiology</subject><subject>Pancreatic Diseases - pathology</subject><subject>Pancreatic Diseases - veterinary</subject><subject>Pancreatic Diseases - virology</subject><subject>Pancreatitis</subject><subject>Prevention</subject><subject>Reoviridae Infections - pathology</subject><subject>Reoviridae Infections - veterinary</subject><subject>Reverse Transcriptase Polymerase Chain Reaction - veterinary</subject><subject>Risk factors</subject><subject>RNA viruses</subject><subject>Salmo salar - virology</subject><subject>Veterinary medicine</subject><issn>1297-9716</issn><issn>0928-4249</issn><issn>1297-9716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptUsFu1DAUjBCIlsIHcEGRuLSHFDuOk_iCtKoKRVoJJHq3HOd511ViB9tZsXw9L9ql2lYohxc_z4z9xpNl7ym5prStP0XKeN0UhNYFYa0o9i-yc1qKphANrV-e_J9lb2J8IAhkvHqdnZVNUwtG2Xn25_b3BMGO4JIa8h82ausg9yFtfQC_s2GOuXUGdLLe5SP0ViWI-RR8OvbURlkXUz4ppwOomPc2YgGk5as0KJeszqMaRsRe_lzqslLh6m32yqghwrtjvcjuv9ze39wV6-9fv92s1oXmZZsKI6CiVds1nSl7LTqjOlNxykSpQVDVAi0J58IYIlotDOMNp53hvdGsUo1hF9nng-w0d3h_jZMGNcgJh1ZhL72y8umOs1u58TvJCSoJjgJXB4HtM9rdai2XHkGbWVWLHUXs5fGw4H_NEJMc0VIY0Abwc5S0ZZyXleAlQj8-gz74OTh0YkHVLSG8PkFt1AASX8LjHfUiKldVjccitEHU9X9Q-PUwWu0dGIv9JwR6IOjgYwxgHgejRC7ZkodsSYyMXLIl98j5cGrkI-NfmNhf-O_L7A</recordid><startdate>20161021</startdate><enddate>20161021</enddate><creator>Lund, Morten</creator><creator>Røsæg, Magnus Vikan</creator><creator>Krasnov, Aleksei</creator><creator>Timmerhaus, Gerrit</creator><creator>Nyman, Ingvild Berg</creator><creator>Aspehaug, Vidar</creator><creator>Rimstad, Espen</creator><creator>Dahle, Maria Krudtaa</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0380-084X</orcidid></search><sort><creationdate>20161021</creationdate><title>Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar)</title><author>Lund, Morten ; 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The most prevalent viral diseases in Norwegian salmon aquaculture are heart and skeletal muscle inflammation (HSMI) caused by Piscine orthoreovirus (PRV), and pancreas disease (PD) caused by Salmonid alphavirus (SAV). Both PRV and SAV target heart and skeletal muscles, but SAV additionally targets exocrine pancreas. PRV and SAV are often present in the same locations and co-infections occur, but the effect of this crosstalk on disease development has not been investigated. In the present experiment, the effect of a primary PRV infection on subsequent SAV infection was studied. Atlantic salmon were infected with PRV by cohabitation, followed by addition of SAV shedder fish 4 or 10 weeks after the initial PRV infection. Histopathological evaluation, monitoring of viral RNA levels and host gene expression analysis were used to assess disease development. Significant reduction of SAV RNA levels and of PD specific histopathological changes were observed in the co-infected groups compared to fish infected by SAV only. A strong correlation was found between histopathological development and expression of disease related genes in heart. In conclusion, experimentally PRV infected salmon are less susceptible to secondary SAV infection and development of PD.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>27769313</pmid><doi>10.1186/s13567-016-0389-y</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0380-084X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alphavirus Alphavirus Infections - complications Alphavirus Infections - pathology Alphavirus Infections - veterinary Alphavirus Infections - virology Animals Atlantic salmon Diseases Fish Diseases - pathology Fish Diseases - virology Life Sciences Medical research Orthoreovirus Pancreatic Diseases - etiology Pancreatic Diseases - pathology Pancreatic Diseases - veterinary Pancreatic Diseases - virology Pancreatitis Prevention Reoviridae Infections - pathology Reoviridae Infections - veterinary Reverse Transcriptase Polymerase Chain Reaction - veterinary Risk factors RNA viruses Salmo salar - virology Veterinary medicine |
| title | Experimental Piscine orthoreovirus infection mediates protection against pancreas disease in Atlantic salmon (Salmo salar) |
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