Facilitation of Hippocampal Kindling and Exacerbation of Kindled Seizures by Intra-CA1 Injection of Quinine: A Possible Role of Cx36 Gap Junctions

GABAergic interneurons in the hippocampal CA1 area are mutually communicated by gap junctions (GJs) composed of connexin36 (Cx36). We examined the role of Cx36 in CA1 in manifestation of kindled seizures and hippocampal kindling in rats. Quinine, as the specific blocker of Cx36, was injected into CA...

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Veröffentlicht in:	Iranian biomedical journal 2016-11, Vol.20 (5), p.266-272
Hauptverfasser:	Etemadi, Fatemeh, Sayyah, Mohammad, Gholami Pourbadie, Hamid, Babapour, Vahab
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Connexins - metabolism Epilepsy Full Lenght Gap Junction delta-2 Protein Gap Junctions - drug effects Gap Junctions - metabolism Hippocampus - drug effects Hippocampus - physiopathology Histology Kindling, Neurologic - drug effects Male Quinine - pharmacology Rats Rats, Wistar Rodents Seizures - physiopathology Synaptic Transmission - drug effects Synaptic Transmission - physiology
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