Emtricitabine-Triphosphate in Dried Blood Spots as a Marker of Recent Dosing

New objective measures of antiretroviral adherence are needed. We determined if emtricitabine triphosphate (FTC-TP) in dried blood spots (DBS) can be used as a marker of recent dosing with tenofovir disoproxil fumarate-emtricitabine (TDF-FTC). The half-life of FTC-TP was estimated in DBS samples obt...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2016-11, Vol.60 (11), p.6692-6697
Hauptverfasser:	Castillo-Mancilla, Jose, Seifert, Sharon, Campbell, Kayla, Coleman, Stacey, McAllister, Kevin, Zheng, Jia-Hua, Gardner, Edward M, Liu, Albert, Glidden, David V, Grant, Robert, Hosek, Sybil, Wilson, Craig M, Bushman, Lane R, MaWhinney, Samantha, Anderson, Peter L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anti-HIV Agents Anti-HIV Agents - blood Anti-HIV Agents - pharmacokinetics Case-Control Studies Dried Blood Spot Testing Dried Blood Spot Testing - methods Drug Administration Schedule Emtricitabine Emtricitabine - blood Emtricitabine - pharmacokinetics Female Half-Life HIV - drug effects HIV - growth & development HIV Infections HIV Infections - blood HIV Infections - drug therapy HIV Infections - virology Humans Lentivirus Male Medication Adherence Medication Adherence - statistics & numerical data Middle Aged Pharmacology Prospective Studies Retroviridae Tenofovir Tenofovir - blood Tenofovir - pharmacokinetics
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