Cyclooxygenase-2 Mediated Oxidation of 2-Arachidonoyl-Lysophospholipids Identifies Unknown Lipid Signaling Pathways

Eicosanoid lipids play important roles in cellular signaling as second messengers in inflammation, immune response, vascular tone, and the CNS. Biosynthesis of eicosanoid lipids proceeds via hydrolysis of esterified arachidonic acid from phospholipids followed by oxidation of the released arachidoni...

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Veröffentlicht in:	Cell chemical biology 2016-10, Vol.23 (10), p.1217-1227
Hauptverfasser:	Liu, Xinping, Moon, Sung Ho, Jenkins, Christopher M., Sims, Harold F., Gross, Richard W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonic Acid - metabolism Calcium - metabolism Cells, Cultured Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Eicosanoids - metabolism Fibroblasts - metabolism Gene Deletion Group VI Phospholipases A2 - genetics Group VI Phospholipases A2 - metabolism Humans Liver - metabolism Lysophospholipids - metabolism Mice Models, Molecular Oxidation-Reduction Signal Transduction
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