The control of the discrimination between dNTP and rNTP in DNA and RNA polymerase

ABSTRACT Understanding the origin of discrimination between rNTP and dNTP by DNA/RNA polymerases is important both for gaining fundamental knowledge on the corresponding systems and for advancing the design of specific drugs. This work explores the nature of this discrimination by systematic calcula...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2016-11, Vol.84 (11), p.1616-1624
Hauptverfasser:	Yoon, Hanwool, Warshel, Arieh
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Dinucleoside Phosphates - chemistry Dinucleoside Phosphates - metabolism DNA polymerase DNA-Directed DNA Polymerase - chemistry DNA-Directed DNA Polymerase - metabolism DNA-Directed RNA Polymerases - chemistry DNA-Directed RNA Polymerases - metabolism enzyme catalysis free energy perturbation internal water in proteins Kinetics Models, Molecular Protein Binding Protein Domains Protein Structure, Secondary Ribonucleotides - chemistry Ribonucleotides - metabolism RNA polymerase Static Electricity Substrate Specificity sugar selectivity Thermodynamics Viral Proteins - chemistry Viral Proteins - metabolism Water - chemistry
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