Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone

We tested the hypothesis that angiotensin II-induced hypertension is associated with an increase in vascular .O2- production, and characterized the oxidase involved in this process. Infusion of angiotensin II (0.7 mg/kg per d) increased systolic blood pressure and doubled vascular .O2- production (a...

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Veröffentlicht in:	The Journal of clinical investigation 1996-04, Vol.97 (8), p.1916-1923
Hauptverfasser:	Rajagopalan, S, Kurz, S, Münzel, T, Tarpey, M, Freeman, B A, Griendling, K K, Harrison, D G
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - pharmacology Angiotensin II - pharmacology Animals Antihypertensive Agents - pharmacology Aorta Arginine - analogs & derivatives Arginine - pharmacology Biphenyl Compounds - pharmacology Calcimycin - pharmacology Endothelium, Vascular - physiology Enzyme Activation Enzyme Inhibitors - pharmacology Hypertension - chemically induced Hypertension - physiopathology Imidazoles - pharmacology In Vitro Techniques Losartan Male Muscle Relaxation - drug effects Muscle Tonus - drug effects Muscle Tonus - physiology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Muscle, Smooth, Vascular - physiopathology NADH, NADPH Oxidoreductases - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitroglycerin - pharmacology Norepinephrine - pharmacology omega-N-Methylarginine Rats Rats, Sprague-Dawley Superoxide Dismutase - pharmacology Superoxides - metabolism Tetrazoles - pharmacology
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