High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice

Background and Purpose Human pancreatic polypeptide (hPP) is known to suppress appetite and food intake, thereby representing a potential therapeutic approach against obesity and associated metabolic disorders. The aim of this study was to improve hPP stability by covalent PEGylation with diverse mo...

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Veröffentlicht in:	British journal of pharmacology 2016-11, Vol.173 (22), p.3208-3221
Hauptverfasser:	Thieme, V, Jolly, N, Madsen, A N, Bellmann‐Sickert, K, Schwartz, T W, Holst, B, Cox, H M, Beck‐Sickinger, A G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Appetite Bioavailability Blood plasma Cell lines Drug development Eating - drug effects Epithelial cells Food Food intake Humans Incubation Latency Liver Male Metabolic disorders Mice Mice, Inbred C57BL Molecular Weight Mucosa Pancreatic Polypeptide - chemistry Pancreatic Polypeptide - metabolism Pancreatic Polypeptide - pharmacology Peptide synthesis Peptides Polyethylene glycol Polyethylene Glycols - metabolism Polypeptides Research Paper Research Papers Rodents
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