Chronic cardiac rejection in the LEW to F344 rat model. Blockade of CD28-B7 costimulation by CTLA4Ig modulates T cell and macrophage activation and attenuates arteriosclerosis

CTLA4Ig, a fusion protein that blocks CD28-B7 costimulation, was studied in a LEW to F344 rat model of chronic cardiac rejection. In rats treated with a single dose of CTLA4Ig (0.5 mg intraperitoneally) 2 d after transplantation, allografts survived significantly longer ( > 70 d in 64%) than in u...

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Veröffentlicht in:	The Journal of clinical investigation 1996-02, Vol.97 (3), p.833-838
Hauptverfasser:	Russell, M E, Hancock, W W, Akalin, E, Wallace, A F, Glysing-Jensen, T, Willett, T A, Sayegh, M H
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Animals Antigens, CD - drug effects Antigens, Differentiation - pharmacology Arteriosclerosis - prevention & control B7-1 Antigen - drug effects Base Sequence CD28 Antigens - drug effects Coronary Vessels - pathology CTLA-4 Antigen Graft Rejection - immunology Heart Transplantation - immunology Immunoconjugates Immunohistochemistry Immunosuppressive Agents - pharmacology Lymphocyte Activation - drug effects Macrophage Activation - drug effects Molecular Sequence Data Rats Rats, Inbred F344 Transplantation, Homologous Up-Regulation
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