Association of Human Papillomavirus and p16 Status With Outcomes in the IMCL-9815 Phase III Registration Trial for Patients With Locoregionally Advanced Oropharyngeal Squamous Cell Carcinoma of the Head and Neck Treated With Radiotherapy With or Without Cetuximab

We conducted a retrospective evaluation of the IMCL-9815 study to examine the association of human papillomavirus (HPV) and p16 protein expression status with outcomes in patients with oropharyngeal carcinoma (OPC) receiving radiotherapy (RT) plus cetuximab or RT alone. In the IMCL-9815 study, patie...

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Veröffentlicht in:	Journal of clinical oncology 2016-04, Vol.34 (12), p.1300-1308
Hauptverfasser:	Rosenthal, David I, Harari, Paul M, Giralt, Jordi, Bell, Diana, Raben, David, Liu, Joyce, Schulten, Jeltje, Ang, Kian K, Bonner, James A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - chemistry Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Carcinoma, Squamous Cell - virology Cetuximab - adverse effects Cetuximab - therapeutic use Chemoradiotherapy - adverse effects Clinical Trials, Phase III as Topic Cyclin-Dependent Kinase Inhibitor p16 - analysis Disease-Free Survival DNA, Viral - genetics Female Head and Neck Neoplasms - chemistry Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy Head and Neck Neoplasms - virology Human Papillomavirus DNA Tests Humans Immunohistochemistry Kaplan-Meier Estimate Male Middle Aged ORIGINAL REPORTS Oropharyngeal Neoplasms - chemistry Oropharyngeal Neoplasms - mortality Oropharyngeal Neoplasms - pathology Oropharyngeal Neoplasms - therapy Oropharyngeal Neoplasms - virology Papillomaviridae - genetics Papillomaviridae - isolation & purification Predictive Value of Tests Proportional Hazards Models Randomized Controlled Trials as Topic Retrospective Studies Squamous Cell Carcinoma of Head and Neck Time Factors Treatment Outcome
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