Survival and Functionality of Human Induced Pluripotent Stem Cell‐Derived Oligodendrocytes in a Nonhuman Primate Model for Multiple Sclerosis

In this study, human induced pluripotent stem cells (hiPSCs) were differentiated into oligodendrocyte precursor cells (OPCs) and their proper functionality was validated in vitro and in vivo in mouse models for multiple sclerosis (MS). hiPSC‐derived OPCs were injected intracerebrally in a marmoset m...

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Veröffentlicht in:	Stem cells translational medicine 2016-11, Vol.5 (11), p.1550-1561
Hauptverfasser:	Thiruvalluvan, Arun, Czepiel, Marcin, Kap, Yolanda A., Mantingh-Otter, Ietje, Vainchtein, Ilia, Kuipers, Jeroen, Bijlard, Marjolein, Baron, Wia, Giepmans, Ben, Brück, Wolfgang, ’t Hart, Bert A., Boddeke, Erik, Copray, Sjef
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Axons Cell differentiation Corpus callosum Data analysis Enabling Technologies for Cell-Based Clinical Translation Experiments Glial stem cells Growth factors Hypotheses Monkeys & apes Multiple sclerosis Myelination Neurodegeneration Nonhuman primates Oligodendrocytes Pluripotency Stem cell transplantation Stem cells Studies Writing
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