Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs

This study was designed to determine the potential of IGF-1 as a neuronal rescue agent after cerebral ischemia. Unanesthetized late gestation fetal sheep were subjected to 30-min cerebral ischemia by inflation of carotid artery occluder cuffs. 2 h later either 0.1 microgram rhIGF-1, 1 microgram rhIG...

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Veröffentlicht in:	The Journal of clinical investigation 1996-01, Vol.97 (2), p.300-308
Hauptverfasser:	Johnston, B M, Mallard, E C, Williams, C E, Gluckman, P D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Ischemia - drug therapy Dose-Response Relationship, Drug Fetal Hypoxia - drug therapy Insulin-Like Growth Factor I - therapeutic use Ischemia - drug therapy Recombinant Proteins Seizures - prevention & control Sheep Time Factors
Online-Zugang:	Volltext
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