Formaldehyde Induces Rho-Associated Kinase Activity to Evoke Airway Hyperresponsiveness

Formaldehyde, a common indoor air pollutant, exacerbates asthma and synergizes with allergen to induce airway hyperresponsiveness (AHR) in animal models. The mechanisms mediating formaldehyde-induced AHR remain poorly understood. We posit that formaldehyde modulates agonist-induced contractile respo...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2016-10, Vol.55 (4), p.542-553
Hauptverfasser:	Jude, Joseph, Koziol-White, Cynthia, Scala, Jacqueline, Yoo, Edwin, Jester, William, Maute, Christopher, Dalton, Pamela, Panettieri, Jr, Reynold
Format:	Artikel
Sprache:	eng
Schlagworte:	Air pollution Aldehydes Asthma Gene expression Homeostasis Inflammation Kinases Occupational safety Original Research Phosphatase Phosphorylation Pollutants Proteins Smooth muscle Studies
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