Optimization of a novel series of pyranopyridine RND efflux pump inhibitors

Highlights • Efflux pumps play a major role in multidrug resistance (MDR) in bacteria. • RND family efflux pumps are the major MDR pumps in the Gram-negative pathogens. • Efflux pump inhibitors (EPIs) increase antibiotic efficacy and decrease resistance. • Recent advances in optimizing novel RND-tar...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Current opinion in microbiology 2016-10, Vol.33, p.1-6
Hauptverfasser:	Aron, Zachary, Opperman, Timothy J
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Carrier Proteins - antagonists & inhibitors Drug Resistance, Multiple, Bacterial - genetics Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - antagonists & inhibitors Membrane Transport Proteins - metabolism Pathology Pyrans - pharmacology Pyridines - pharmacology Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Efflux pumps play a major role in multidrug resistance (MDR) in bacteria. • RND family efflux pumps are the major MDR pumps in the Gram-negative pathogens. • Efflux pump inhibitors (EPIs) increase antibiotic efficacy and decrease resistance. • Recent advances in optimizing novel RND-targeting pyranopyridine EPIs are reviewed.
ISSN:	1369-5274 1879-0364
DOI:	10.1016/j.mib.2016.05.007