Elevated ERK/p90 ribosomal S6 kinase activity underlies audiogenic seizure susceptibility in fragile X mice

Fragile X syndrome (FXS) is the most common heritable cause of intellectual disability and a leading genetic form of autism. The Fmr1 KO mouse, a model of FXS, exhibits elevated translation in the hippocampus and the cortex. ERK (extracellular signal-regulated kinase) and mTOR (mechanistic target of...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-10, Vol.113 (41), p.E6290-E6297
Hauptverfasser:	Sawicka, Kirsty, Pyronneau, Alexander, Chao, Miranda, Bennett, Michael V. L., Zukin, R. Suzanne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autism Biological Sciences Brain Cerebral Cortex - metabolism Cerebral Cortex - physiopathology Convulsions & seizures Disease Models, Animal DNA-Binding Proteins - metabolism Epilepsy, Reflex - drug therapy Epilepsy, Reflex - etiology Epilepsy, Reflex - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Fragile X Mental Retardation Protein - genetics Fragile X Mental Retardation Protein - metabolism Fragile X Syndrome - complications Mice Mice, Knockout Neurons - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation PNAS Plus Protein synthesis Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors Ribosomal Protein S6 Kinases, 90-kDa - metabolism Rodents Seizures - etiology Seizures - metabolism Signal Transduction Synapses - metabolism TOR Serine-Threonine Kinases - metabolism Transcription Factors - metabolism
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