Innate immune responses to influenza A H5N1: friend or foe?

Avian influenza A H5N1 remains unusual in its virulence for humans. Although infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia that leads to acute respiratory distress syndrome and death, but its pathogenesis remains an enigma. Compar...

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Veröffentlicht in:Trends in immunology 2009-12, Vol.30 (12), p.574-584
Hauptverfasser: Peiris, Joseph Sriyal Malik, Cheung, Chung Yan, Leung, Connie Yin Hung, Nicholls, John Malcolm
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container_issue 12
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container_title Trends in immunology
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creator Peiris, Joseph Sriyal Malik
Cheung, Chung Yan
Leung, Connie Yin Hung
Nicholls, John Malcolm
description Avian influenza A H5N1 remains unusual in its virulence for humans. Although infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia that leads to acute respiratory distress syndrome and death, but its pathogenesis remains an enigma. Comparison of the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1) and H5N1 in patients, animal models and relevant primary human cell cultures is instructive. Although the direct effects of viral replication and differences in the tropism of the virus for cells in the lower respiratory tract clearly contribute to pathogenesis, we focus here on the possible contribution of the host innate immune response in the pathogenesis of this disease.
doi_str_mv 10.1016/j.it.2009.09.004
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subjects Allergy and Immunology
Animals
Genes
Humans
Immunity, Innate
Infections
Influenza A Virus, H1N1 Subtype
Influenza A Virus, H1N1 Subtype - immunology
Influenza A Virus, H1N1 Subtype - pathogenicity
Influenza A Virus, H3N2 Subtype
Influenza A Virus, H3N2 Subtype - immunology
Influenza A Virus, H3N2 Subtype - pathogenicity
Influenza A Virus, H5N1 Subtype
Influenza A Virus, H5N1 Subtype - immunology
Influenza A Virus, H5N1 Subtype - pathogenicity
Influenza, Human
Influenza, Human - epidemiology
Influenza, Human - immunology
Influenza, Human - pathology
Influenza, Human - physiopathology
Interferons
Interferons - metabolism
Life Sciences
Mice
Microbiology and Parasitology
Mutation
Orthomyxoviridae Infections
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - physiopathology
Pandemics
Respiratory distress syndrome
Respiratory Distress Syndrome, Adult
Respiratory Distress Syndrome, Adult - immunology
Tumor Necrosis Factor-alpha
Tumor Necrosis Factor-alpha - metabolism
Virology
title Innate immune responses to influenza A H5N1: friend or foe?
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