Innate immune responses to influenza A H5N1: friend or foe?
Avian influenza A H5N1 remains unusual in its virulence for humans. Although infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia that leads to acute respiratory distress syndrome and death, but its pathogenesis remains an enigma. Compar...
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Veröffentlicht in: | Trends in immunology 2009-12, Vol.30 (12), p.574-584 |
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description | Avian influenza A H5N1 remains unusual in its virulence for humans. Although infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia that leads to acute respiratory distress syndrome and death, but its pathogenesis remains an enigma. Comparison of the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1) and H5N1 in patients, animal models and relevant primary human cell cultures is instructive. Although the direct effects of viral replication and differences in the tropism of the virus for cells in the lower respiratory tract clearly contribute to pathogenesis, we focus here on the possible contribution of the host innate immune response in the pathogenesis of this disease. |
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Although infection of humans remains inefficient, many of those with H5N1 disease have a rapidly progressing viral pneumonia that leads to acute respiratory distress syndrome and death, but its pathogenesis remains an enigma. Comparison of the virology and pathogenesis of human seasonal influenza viruses (H3N2 and H1N1) and H5N1 in patients, animal models and relevant primary human cell cultures is instructive. 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subjects | Allergy and Immunology Animals Genes Humans Immunity, Innate Infections Influenza A Virus, H1N1 Subtype Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H1N1 Subtype - pathogenicity Influenza A Virus, H3N2 Subtype Influenza A Virus, H3N2 Subtype - immunology Influenza A Virus, H3N2 Subtype - pathogenicity Influenza A Virus, H5N1 Subtype Influenza A Virus, H5N1 Subtype - immunology Influenza A Virus, H5N1 Subtype - pathogenicity Influenza, Human Influenza, Human - epidemiology Influenza, Human - immunology Influenza, Human - pathology Influenza, Human - physiopathology Interferons Interferons - metabolism Life Sciences Mice Microbiology and Parasitology Mutation Orthomyxoviridae Infections Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - physiopathology Pandemics Respiratory distress syndrome Respiratory Distress Syndrome, Adult Respiratory Distress Syndrome, Adult - immunology Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha - metabolism Virology |
title | Innate immune responses to influenza A H5N1: friend or foe? |
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