Integrated Genomics Reveals Convergent Transcriptomic Networks Underlying Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis

Despite shared environmental exposures, idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease are usually studied in isolation, and the presence of shared molecular mechanisms is unknown. We applied an integrative genomic approach to identify convergent transcriptomic pathway...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2016-10, Vol.194 (8), p.948-960
Hauptverfasser:	Kusko, Rebecca L, Brothers, 2nd, John F, Tedrow, John, Pandit, Kusum, Huleihel, Luai, Perdomo, Catalina, Liu, Gang, Juan-Guardela, Brenda, Kass, Daniel, Zhang, Sherry, Lenburg, Marc, Martinez, Fernando, Quackenbush, John, Sciurba, Frank, Limper, Andrew, Geraci, Mark, Yang, Ivana, Schwartz, David A, Beane, Jennifer, Spira, Avrum, Kaminski, Naftali
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Emphysema - genetics Female Gene Regulatory Networks - genetics Humans Hypoxia-Inducible Factor 1, alpha Subunit - metabolism I-kappa B Proteins - metabolism Idiopathic Pulmonary Fibrosis - genetics Male Membrane Proteins - metabolism Middle Aged Nerve Tissue Proteins - metabolism Oligonucleotide Array Sequence Analysis Original Platelet-Derived Growth Factor - metabolism Proto-Oncogene Proteins c-mdm2 - metabolism Pulmonary Disease, Chronic Obstructive - genetics
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