Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot

Cell metabolism and growth are matched to nutrient availability via the amino-acid-regulated mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as important amino acid sensors controlling mTOR recruitment and activation at the surface of multiple intracellular compartments...

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Veröffentlicht in:	Cell metabolism 2016-04, Vol.23 (4), p.580-589
Hauptverfasser:	Goberdhan, Deborah C.I., Wilson, Clive, Harris, Adrian L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Transport Systems - metabolism Amino Acids - metabolism Animals Biological Transport Endosomes - metabolism Golgi Apparatus - metabolism Humans Lysosomes - metabolism Mechanistic Target of Rapamycin Complex 1 Multiprotein Complexes - metabolism Signal Transduction TOR Serine-Threonine Kinases - metabolism
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