Codon optimality controls differential mRNA translation during amino acid starvation

It is common wisdom that codon usage bias has evolved in the selection for efficient translation, in which highly expressed genes are encoded predominantly by optimal codons. However, a growing body of evidence suggests regulatory roles for non-optimal codons in translation dynamics. Here we report...

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Veröffentlicht in:	RNA (Cambridge) 2016-11, Vol.22 (11), p.1719-1727
Hauptverfasser:	Saikia, Mridusmita, Wang, Xiaoyun, Mao, Yuanhui, Wan, Ji, Pan, Tao, Qian, Shu-Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Codon Escherichia coli Protein Biosynthesis Ribosomes - metabolism RNA, Messenger - genetics RNA, Transfer - genetics
Online-Zugang:	Volltext
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