TUT7 catalyzes the uridylation of the 3' end for rapid degradation of histone mRNA

The replication-dependent histone mRNAs end in a stem-loop instead of the poly(A) tail present at the 3' end of all other cellular mRNAs. Following processing, the 3' end of histone mRNAs is trimmed to 3 nucleotides (nt) after the stem-loop, and this length is maintained by addition of non...

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Veröffentlicht in:	RNA (Cambridge) 2016-11, Vol.22 (11), p.1673-1688
Hauptverfasser:	Lackey, Patrick E, Welch, Joshua D, Marzluff, William F
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis DNA Replication Gene Knockdown Techniques HeLa Cells Histones - genetics Humans Hydrolysis RNA Nucleotidyltransferases - chemistry RNA Nucleotidyltransferases - genetics RNA Nucleotidyltransferases - metabolism RNA, Messenger - metabolism Uridine - metabolism
Online-Zugang:	Volltext
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