Long-term outcomes of letrozole treatment for precocious puberty in girls with McCune–Albright syndrome

Objective McCune–Albright syndrome (MAS) is a rare disorder with a broad spectrum including precocious puberty (PP) due to recurrent estrogen-secreting ovarian cysts. This study evaluates the long-term safety and efficacy of letrozole treatment in large cohort of girls with MAS-associated PP. Design...

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Veröffentlicht in:	European journal of endocrinology 2016-11, Vol.175 (5), p.477-483
Hauptverfasser:	Estrada, Andrea, Boyce, Alison M, Brillante, Beth A, Guthrie, Lori C, Gafni, Rachel I, Collins, Michael T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatase Inhibitors - administration & dosage Body Height - drug effects Body Height - physiology Child Child, Preschool Clinical Study Cohort Studies Drug Administration Schedule Female Fibrous Dysplasia, Polyostotic - diagnosis Fibrous Dysplasia, Polyostotic - drug therapy Fibrous Dysplasia, Polyostotic - physiopathology Humans Infant Nitriles - administration & dosage Pilot Projects Puberty, Precocious - diagnosis Puberty, Precocious - drug therapy Puberty, Precocious - physiopathology Retrospective Studies Time Factors Treatment Outcome Triazoles - administration & dosage
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