CD14brightCD16- monocytes and sCD14 level negatively associate with CD4-memory T-cell frequency and predict HCV-decline on therapy
During HIV+HCV+ co-infection CD14 bright CD16 - -monocytes produce soluble immune-activation markers that predict disease-progression and poor IFNα-treatment response. We evaluated relationships among immune-activation, monocyte phenotype, CD4-memory T-cells and HCV-, CMV- and CMV/EBV/Influenza (CEF...
Gespeichert in:
| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2016-11, Vol.73 (3), p.258-262 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 262 |
|---|---|
| container_issue | 3 |
| container_start_page | 258 |
| container_title | Journal of acquired immune deficiency syndromes (1999) |
| container_volume | 73 |
| creator | Judge, Chelsey J Sandberg, Johan K Funderburg, Nicholas T Sherman, Ken E Butt, Adeel A Kang, Minhee Landay, Alan L Lederman, Michael M Anthony, Donald D |
| description | During HIV+HCV+ co-infection CD14
bright
CD16
-
-monocytes produce soluble immune-activation markers that predict disease-progression and poor IFNα-treatment response. We evaluated relationships among immune-activation, monocyte phenotype, CD4-memory T-cells and HCV-, CMV- and CMV/EBV/Influenza (CEF)-specific IFNγ-response, before and during IFNα-treatment. Effector-memory and central-memory CD4-T-cell frequencies were lower in HCV+HIV+ than uninfected-donors, and correlated negatively with HCV-level, CD14
bright
CD16
-
-monocytes and plasma sCD14. sCD14 and CD14
bright
CD16
-
monocytes negatively correlated with IFNα-dependent HCV-decline. sCD14 negatively associated with and CD4 effector-memory T-cells positively-associated with CEF-specific IFNγ-response. These data support a role for memory-CD4 T-cells in HCV-containment, and link immune-activation and CD14
bright
CD16
-
-monocyte frequency to failure of interferon-dependent HCV-clearance. |
| doi_str_mv | 10.1097/QAI.0000000000001104 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmedcentral</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5065372</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>pubmedcentral_primary_oai_pubmedcentral_nih_gov_5065372</sourcerecordid><originalsourceid>FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_50653723</originalsourceid><addsrcrecordid>eNqljMtOwzAURC0EouXxByzuD7jEifPaIKEUVJZIFdvIdW4TI8cOtlvkLV9OQCxgzWzmSGc0hNywZMWSurx9vn9aJb_CWMJPyJLVnNOyqvjpzHmaU86yfEEuvH-dNwXn9TlZpGWaV2nGluSjWTO-c6ofwkwFhdEaK2NAD8J04L80aDyiBoO9CGqmCMJ7K5UICO8qDNCsOR1xtC7ClkrUGvYO3w5oZPx-mRx2SgbYNC-0Q6mVQbAGwoBOTPGKnO2F9nj905fk7vFh22zodNiN2Ek0wQndTk6NwsXWCtX-NUYNbW-PbZ4UeVam2b8PPgHH4m85</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>CD14brightCD16- monocytes and sCD14 level negatively associate with CD4-memory T-cell frequency and predict HCV-decline on therapy</title><source>Journals@Ovid LWW Legacy Archive</source><source>Journals@Ovid Complete</source><source>Free E- Journals</source><creator>Judge, Chelsey J ; Sandberg, Johan K ; Funderburg, Nicholas T ; Sherman, Ken E ; Butt, Adeel A ; Kang, Minhee ; Landay, Alan L ; Lederman, Michael M ; Anthony, Donald D</creator><creatorcontrib>Judge, Chelsey J ; Sandberg, Johan K ; Funderburg, Nicholas T ; Sherman, Ken E ; Butt, Adeel A ; Kang, Minhee ; Landay, Alan L ; Lederman, Michael M ; Anthony, Donald D</creatorcontrib><description>During HIV+HCV+ co-infection CD14
bright
CD16
-
-monocytes produce soluble immune-activation markers that predict disease-progression and poor IFNα-treatment response. We evaluated relationships among immune-activation, monocyte phenotype, CD4-memory T-cells and HCV-, CMV- and CMV/EBV/Influenza (CEF)-specific IFNγ-response, before and during IFNα-treatment. Effector-memory and central-memory CD4-T-cell frequencies were lower in HCV+HIV+ than uninfected-donors, and correlated negatively with HCV-level, CD14
bright
CD16
-
-monocytes and plasma sCD14. sCD14 and CD14
bright
CD16
-
monocytes negatively correlated with IFNα-dependent HCV-decline. sCD14 negatively associated with and CD4 effector-memory T-cells positively-associated with CEF-specific IFNγ-response. These data support a role for memory-CD4 T-cells in HCV-containment, and link immune-activation and CD14
bright
CD16
-
-monocyte frequency to failure of interferon-dependent HCV-clearance.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/QAI.0000000000001104</identifier><identifier>PMID: 27258231</identifier><language>eng</language><ispartof>Journal of acquired immune deficiency syndromes (1999), 2016-11, Vol.73 (3), p.258-262</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids></links><search><creatorcontrib>Judge, Chelsey J</creatorcontrib><creatorcontrib>Sandberg, Johan K</creatorcontrib><creatorcontrib>Funderburg, Nicholas T</creatorcontrib><creatorcontrib>Sherman, Ken E</creatorcontrib><creatorcontrib>Butt, Adeel A</creatorcontrib><creatorcontrib>Kang, Minhee</creatorcontrib><creatorcontrib>Landay, Alan L</creatorcontrib><creatorcontrib>Lederman, Michael M</creatorcontrib><creatorcontrib>Anthony, Donald D</creatorcontrib><title>CD14brightCD16- monocytes and sCD14 level negatively associate with CD4-memory T-cell frequency and predict HCV-decline on therapy</title><title>Journal of acquired immune deficiency syndromes (1999)</title><description>During HIV+HCV+ co-infection CD14
bright
CD16
-
-monocytes produce soluble immune-activation markers that predict disease-progression and poor IFNα-treatment response. We evaluated relationships among immune-activation, monocyte phenotype, CD4-memory T-cells and HCV-, CMV- and CMV/EBV/Influenza (CEF)-specific IFNγ-response, before and during IFNα-treatment. Effector-memory and central-memory CD4-T-cell frequencies were lower in HCV+HIV+ than uninfected-donors, and correlated negatively with HCV-level, CD14
bright
CD16
-
-monocytes and plasma sCD14. sCD14 and CD14
bright
CD16
-
monocytes negatively correlated with IFNα-dependent HCV-decline. sCD14 negatively associated with and CD4 effector-memory T-cells positively-associated with CEF-specific IFNγ-response. These data support a role for memory-CD4 T-cells in HCV-containment, and link immune-activation and CD14
bright
CD16
-
-monocyte frequency to failure of interferon-dependent HCV-clearance.</description><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNqljMtOwzAURC0EouXxByzuD7jEifPaIKEUVJZIFdvIdW4TI8cOtlvkLV9OQCxgzWzmSGc0hNywZMWSurx9vn9aJb_CWMJPyJLVnNOyqvjpzHmaU86yfEEuvH-dNwXn9TlZpGWaV2nGluSjWTO-c6ofwkwFhdEaK2NAD8J04L80aDyiBoO9CGqmCMJ7K5UICO8qDNCsOR1xtC7ClkrUGvYO3w5oZPx-mRx2SgbYNC-0Q6mVQbAGwoBOTPGKnO2F9nj905fk7vFh22zodNiN2Ek0wQndTk6NwsXWCtX-NUYNbW-PbZ4UeVam2b8PPgHH4m85</recordid><startdate>20161101</startdate><enddate>20161101</enddate><creator>Judge, Chelsey J</creator><creator>Sandberg, Johan K</creator><creator>Funderburg, Nicholas T</creator><creator>Sherman, Ken E</creator><creator>Butt, Adeel A</creator><creator>Kang, Minhee</creator><creator>Landay, Alan L</creator><creator>Lederman, Michael M</creator><creator>Anthony, Donald D</creator><scope>5PM</scope></search><sort><creationdate>20161101</creationdate><title>CD14brightCD16- monocytes and sCD14 level negatively associate with CD4-memory T-cell frequency and predict HCV-decline on therapy</title><author>Judge, Chelsey J ; Sandberg, Johan K ; Funderburg, Nicholas T ; Sherman, Ken E ; Butt, Adeel A ; Kang, Minhee ; Landay, Alan L ; Lederman, Michael M ; Anthony, Donald D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmedcentral_primary_oai_pubmedcentral_nih_gov_50653723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Judge, Chelsey J</creatorcontrib><creatorcontrib>Sandberg, Johan K</creatorcontrib><creatorcontrib>Funderburg, Nicholas T</creatorcontrib><creatorcontrib>Sherman, Ken E</creatorcontrib><creatorcontrib>Butt, Adeel A</creatorcontrib><creatorcontrib>Kang, Minhee</creatorcontrib><creatorcontrib>Landay, Alan L</creatorcontrib><creatorcontrib>Lederman, Michael M</creatorcontrib><creatorcontrib>Anthony, Donald D</creatorcontrib><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Judge, Chelsey J</au><au>Sandberg, Johan K</au><au>Funderburg, Nicholas T</au><au>Sherman, Ken E</au><au>Butt, Adeel A</au><au>Kang, Minhee</au><au>Landay, Alan L</au><au>Lederman, Michael M</au><au>Anthony, Donald D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CD14brightCD16- monocytes and sCD14 level negatively associate with CD4-memory T-cell frequency and predict HCV-decline on therapy</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><date>2016-11-01</date><risdate>2016</risdate><volume>73</volume><issue>3</issue><spage>258</spage><epage>262</epage><pages>258-262</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><abstract>During HIV+HCV+ co-infection CD14
bright
CD16
-
-monocytes produce soluble immune-activation markers that predict disease-progression and poor IFNα-treatment response. We evaluated relationships among immune-activation, monocyte phenotype, CD4-memory T-cells and HCV-, CMV- and CMV/EBV/Influenza (CEF)-specific IFNγ-response, before and during IFNα-treatment. Effector-memory and central-memory CD4-T-cell frequencies were lower in HCV+HIV+ than uninfected-donors, and correlated negatively with HCV-level, CD14
bright
CD16
-
-monocytes and plasma sCD14. sCD14 and CD14
bright
CD16
-
monocytes negatively correlated with IFNα-dependent HCV-decline. sCD14 negatively associated with and CD4 effector-memory T-cells positively-associated with CEF-specific IFNγ-response. These data support a role for memory-CD4 T-cells in HCV-containment, and link immune-activation and CD14
bright
CD16
-
-monocyte frequency to failure of interferon-dependent HCV-clearance.</abstract><pmid>27258231</pmid><doi>10.1097/QAI.0000000000001104</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1525-4135 |
| ispartof | Journal of acquired immune deficiency syndromes (1999), 2016-11, Vol.73 (3), p.258-262 |
| issn | 1525-4135 1944-7884 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5065372 |
| source | Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; Free E- Journals |
| title | CD14brightCD16- monocytes and sCD14 level negatively associate with CD4-memory T-cell frequency and predict HCV-decline on therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T17%3A14%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmedcentral&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CD14brightCD16-%20monocytes%20and%20sCD14%20level%20negatively%20associate%20with%20CD4-memory%20T-cell%20frequency%20and%20predict%20HCV-decline%20on%20therapy&rft.jtitle=Journal%20of%20acquired%20immune%20deficiency%20syndromes%20(1999)&rft.au=Judge,%20Chelsey%20J&rft.date=2016-11-01&rft.volume=73&rft.issue=3&rft.spage=258&rft.epage=262&rft.pages=258-262&rft.issn=1525-4135&rft.eissn=1944-7884&rft_id=info:doi/10.1097/QAI.0000000000001104&rft_dat=%3Cpubmedcentral%3Epubmedcentral_primary_oai_pubmedcentral_nih_gov_5065372%3C/pubmedcentral%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/27258231&rfr_iscdi=true |